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rs12402521

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 2 12–15 mmHg higher blood pressure when under stress
Make rs12402521(A;A)
Make rs12402521(A;G)
ReferenceGRCh38 38.1/141
Chromosome1
Position186453389
GenePDC
is asnp
is mentioned by
dbSNPrs12402521
ebirs12402521
HLIrs12402521
Exacrs12402521
Varsomers12402521
Maprs12402521
PheGenIrs12402521
hapmaprs12402521
1000 genomesrs12402521
hgdprs12402521
ensemblrs12402521
gopubmedrs12402521
geneviewrs12402521
scholarrs12402521
googlers12402521
pharmgkbrs12402521
gwascentralrs12402521
openSNPrs12402521
23andMers12402521
23andMe allrs12402521
SNP Nexus

SNPshotrs12402521
SNPdbers12402521
MSV3drs12402521
GWAS Ctlgrs12402521
GMAF0.3632
Max Magnitude2
? (A;A) (A;G) (G;G) 28

Candidate gene–based association studies in 2 different human populations revealed several SNPs in the PDC gene to be associated with stress-dependent hypertension. Individuals homozygous for the G allele of an intronic PDC SNP (rs12402521) had 12–15 mmHg higher blood pressure than those carrying the A allele.JCI 2009


[PMID 19959875OA-icon.png] Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice


[PMID 22365573] Phosducin rs12402521 polymorphism predicts development of hypertension in young subjects with overweight or obesity