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rs12425791

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) possibly increased risk of stroke
(A;G) mixed evidence of increased risk for stroke
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome12
Position674318
GeneNINJ2
is asnp
is mentioned by
dbSNPrs12425791
ebirs12425791
HLIrs12425791
Exacrs12425791
Varsomers12425791
Maprs12425791
PheGenIrs12425791
hapmaprs12425791
1000 genomesrs12425791
hgdprs12425791
ensemblrs12425791
gopubmedrs12425791
geneviewrs12425791
scholarrs12425791
googlers12425791
pharmgkbrs12425791
gwascentralrs12425791
openSNPrs12425791
23andMers12425791
23andMe allrs12425791
SNP Nexus

SNPshotrs12425791
SNPdbers12425791
MSV3drs12425791
GWAS Ctlgrs12425791
GMAF0.2016
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs12425791 is one of 2 SNPs found near the NINJ2 gene on chromosome 12 associated with increased risk for both total stroke and ischemic stroke, based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is rs11833579.

Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. [PMID 19369658OA-icon.png]

Note: a meta-analysis totaling over 8,000 patients did not replicate any association between either rs12425791 or rs11833579 and ischemic (or incident) stroke.[1]

GWAS snp
PMID [PMID 19369658OA-icon.png]
Trait Stroke
Title Genomewide Association Studies of Stroke
Risk Allele A
P-val 1E-9
Odds Ratio



OMIM601367
Desc
Variant
Relatedalso


[PMID 21722921] NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population


[PMID 21832970] Association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Han population


[PMID 22011019] Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia


[PMID 22212150OA-icon.png] Association between genetic variant on Chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan


[PMID 22429733OA-icon.png] NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions


[PMID 20448654] Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population.


[PMID 21148441] Genetic variant on chromosome 12p13 does not show association to ischemic stroke in 3 Swedish case-control studies.


[PMID 21376321] No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.


[PMID 22297388] Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis.


GET Evidence
rs12425791
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.164062
summary



[PMID 23270316] Association between the Single Nucleotide Polymorphism rs12425791 and Ischemic Stroke in Chinese Populations: New Data and Meta-analysis


[PMID 23596786] [Correlation study on 12p13 single nucleotide polymorphism rs12425791 and Chinese medical syndrome types in ischemic stroke patients of the Han nationality]


[PMID 22938733] Lack of association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Uyghur population


[PMID 22795341] The rs11833579 and rs12425791 polymorphisms and risk of ischemic stroke in an Asian population: a meta-analysis.


[PMID 26312640] Impact of chromosome 12p13 variants on ischemic stroke risk


[PMID 26687183] A Novel Functional Polymorphism in the NINJ2 Promoter Predicts Risk of Large Artery Atherosclerotic Stroke.