|(A;A)||possibly increased risk of stroke|
|(A;G)||mixed evidence of increased risk for stroke|
Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. [PMID 19369658]
|Title||Genomewide Association Studies of Stroke|
[PMID 21722921] NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population
[PMID 21832970] Association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Han population
[PMID 22011019] Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia
[PMID 22212150] Association between genetic variant on Chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan
[PMID 22429733] NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions
[PMID 20448654] Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population.
[PMID 21148441] Genetic variant on chromosome 12p13 does not show association to ischemic stroke in 3 Swedish case-control studies.
[PMID 21376321] No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.
[PMID 22297388] Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23270316] Association between the Single Nucleotide Polymorphism rs12425791 and Ischemic Stroke in Chinese Populations: New Data and Meta-analysis
[PMID 23596786] [Correlation study on 12p13 single nucleotide polymorphism rs12425791 and Chinese medical syndrome types in ischemic stroke patients of the Han nationality]
[PMID 22938733] Lack of association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Uyghur population
[PMID 22795341] The rs11833579 and rs12425791 polymorphisms and risk of ischemic stroke in an Asian population: a meta-analysis.
[PMID 26312640] Impact of chromosome 12p13 variants on ischemic stroke risk
[PMID 26687183] A Novel Functional Polymorphism in the NINJ2 Promoter Predicts Risk of Large Artery Atherosclerotic Stroke.