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rs1258763

From SNPedia

Orientationminus
Stabilizedplus
Make rs1258763(A;A)
Make rs1258763(A;G)
Make rs1258763(G;G)
ReferenceGRCh38 38.1/142
Chromosome15
Position32758222
is asnp
is mentioned by
dbSNPrs1258763
ebirs1258763
HLIrs1258763
Exacrs1258763
Varsomers1258763
Maprs1258763
PheGenIrs1258763
hapmaprs1258763
1000 genomesrs1258763
hgdprs1258763
ensemblrs1258763
gopubmedrs1258763
geneviewrs1258763
scholarrs1258763
googlers1258763
pharmgkbrs1258763
gwascentralrs1258763
openSNPrs1258763
23andMers1258763
23andMe allrs1258763
SNP Nexus

SNPshotrs1258763
SNPdbers1258763
MSV3drs1258763
GWAS Ctlgrs1258763
GMAF0.4605
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 20023658]
Trait Nonsyndromic cleft lip with or without cleft palate
Title Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
Risk Allele A
P-val 0.000001
Odds Ratio 1.52 [1.23-1.86]

blog The two most significant associations found were between nose width and SNP rs1258763 near the GREM1 gene in the German cohort (P=6 × 10?4), and between bizygomatic distance and SNP rs987525 at 8q24.21 near the CCDC26 gene (P=0.017)

[PMID 21694738OA-icon.png] Genetic determination of human facial morphology: links between cleft-lips and normal variation.

Associated with European Facial Appearance 10.1371/journal.pgen.1002932


GET Evidence
rs1258763
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.540323
summary



GWAS snp
PMID [PMID 22863734OA-icon.png]
Trait Orofacial clefts
Title Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
Risk Allele
P-val 2E-6
Odds Ratio NR NR


[PMID 26043427] Association between polymorphisms at the GREM1 locus and the risk of nonsyndromic cleft lip with or without cleft palate in the Polish population