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rs12621278

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
Make rs12621278(A;G)
Make rs12621278(G;G)
ReferenceGRCh38 38.1/141
Chromosome2
Position172446825
GeneITGA6
is asnp
is mentioned by
dbSNPrs12621278
ebirs12621278
HLIrs12621278
Exacrs12621278
Varsomers12621278
Maprs12621278
PheGenIrs12621278
hapmaprs12621278
1000 genomesrs12621278
hgdprs12621278
ensemblrs12621278
gopubmedrs12621278
geneviewrs12621278
scholarrs12621278
googlers12621278
pharmgkbrs12621278
gwascentralrs12621278
openSNPrs12621278
23andMers12621278
23andMe allrs12621278
SNP Nexus

SNPshotrs12621278
SNPdbers12621278
MSV3drs12621278
GWAS Ctlgrs12621278
GMAF0.08953
Max Magnitude0
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 19767753OA-icon.png]
Trait Prostate cancer
Title Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Risk Allele G
P-val 9E-23
Odds Ratio 1.33 [1.25-1.43]


[PMID 20651075OA-icon.png] Prostate Cancer Susceptibility Variants Confer Increased Risk of Disease Progression

According to a 23andMe report, the rs12621278(A;A) genotype is associated with 2.4 times higher risk of progression of prostate cancer. [PMID 20651075OA-icon.png]


[PMID 21820706OA-icon.png] Prostate Cancer Risk Alleles and Their Associations With Other Malignancies


[PMID 21390317OA-icon.png] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.


GET Evidence
rs12621278
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.0625
summary



[PMID 23405784] [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]


[PMID 23620269] Genetic variants in 2q31 and 5p15 are associated with aggressive benign prostatic hyperplasia in a Chinese population.