Have questions? Visit https://www.reddit.com/r/SNPedia

rs1265181

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal
(C;G) 2 increased risk for psoriasis
(G;G) 2.5 possibly increased risk of psoriasis
ReferenceGRCh38 38.1/141
Chromosome6
Position31188008
is asnp
is mentioned by
dbSNPrs1265181
ebirs1265181
HLIrs1265181
Exacrs1265181
Varsomers1265181
Maprs1265181
PheGenIrs1265181
hapmaprs1265181
1000 genomesrs1265181
hgdprs1265181
ensemblrs1265181
gopubmedrs1265181
geneviewrs1265181
scholarrs1265181
googlers1265181
pharmgkbrs1265181
gwascentralrs1265181
openSNPrs1265181
23andMers1265181
23andMe allrs1265181
SNP Nexus

SNPshotrs1265181
SNPdbers1265181
MSV3drs1265181
GWAS Ctlgrs1265181
GMAF0.1102
Max Magnitude2.5
? (C;C) (C;G) (G;G) 28
rs1265181 is a SNP in the HLA region of chromosome 6.

A large study (>6,000 Chinese psoriasis patients and an equal number of controls) found a highly significant association between the minor rs1265181(G) allele and risk for psoriasis.[PMID 19169255] A proxy for this allele is rs1265159(A).

See also: 23andMe blog psoriasis

GWAS snp
PMID [PMID 19169255]
Trait Psoriasis
Title Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
Risk Allele
P-val NS
Odds Ratio 22.62 None



[PMID 21208785] Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population


[PMID 19680446OA-icon.png] Multiple Loci within the major histocompatibility complex confer risk of psoriasis.


[PMID 20369022OA-icon.png] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.


[PMID 20606885OA-icon.png] Genetics of psoriasis and psoriatic arthritis.


GET Evidence
rs1265181
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.111111
summary



[PMID 27073425] Candidate gene polymorphisms and risk of psoriasis: A pilot study