|Title||Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans|
|Odds Ratio||0.10 [0.08-0.12] % SD higher|
The above study shows that genotyping for HMGCR rs1265464 may help identify the subset of individuals who are most likely to achieve a CRC risk reduction and cholesterol lowering with statins. Compared with individuals not taking statins, the unadjusted odds ratio of colorectal cancer among rs12654264(A;A) statin users was 0.3 (CI: 0.18-0.51) and among rs12654264(T;T) statin users, 0.66 (CI: 0.41-1.06, p-interaction 0.0012).
Their data may advance the development of personalized statin use for reducing the risk of cancer as well as cardiovascular disease among the approximately 25 million people currently using statins worldwide.
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[PMID 21149302] Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
|Title||Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.|
|Odds Ratio||2.7106 [2.14-3.28] mg/dL decrease|
[PMID 18802019] Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.
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|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23098650] Impact of variants within seven candidate genes on statin treatment efficacy
|Disease||Low density lipoprotein cholesterol level quantitative trait locus 3|
|CLNDBN||Low density lipoprotein cholesterol level quantitative trait locus 3|
|CLNSRC||OMIM Allelic Variant|