According to [PMID 16822964
], variations at rs12704795
, originally known as rs17876088
, located in an intron of the PON2
gene, appear to modulate both susceptibility to, and protection from, the sporadic form of ALS
(Lou Gehrig's disease).
[PMID 17096118] Paraoxonase 2 (PON2) polymorphisms and development of renal dysfunction in type 2 diabetes: UKPDS 76.
[PMID 19546579] Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican Americans.
[PMID 21223581] Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.