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rs12733102

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common in complete genomics
Make rs12733102(C;C)
Make rs12733102(C;G)
ReferenceGRCh38 38.1/141
Chromosome1
Position17336210
GenePADI4
is asnp
is mentioned by
dbSNPrs12733102
ebirs12733102
HLIrs12733102
Exacrs12733102
Varsomers12733102
Maprs12733102
PheGenIrs12733102
hapmaprs12733102
1000 genomesrs12733102
hgdprs12733102
ensemblrs12733102
gopubmedrs12733102
geneviewrs12733102
scholarrs12733102
googlers12733102
pharmgkbrs12733102
gwascentralrs12733102
openSNPrs12733102
23andMers12733102
23andMe allrs12733102
SNP Nexus

SNPshotrs12733102
SNPdbers12733102
MSV3drs12733102
GWAS Ctlgrs12733102
GMAF0.01286
Max Magnitude0
? (C;C) (C;G) (G;G) 28
Venter snp
Source plos
Gene PADI4
allele C
frequency 0.009
sift TOLERATED
HuRef 1103675033992
Disease Association PADI4 is thought to be a rheumatoid arthritis susceptibility locus (MIM:180300). Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.



Neighborrs1748033
Distance43
Neighborrs1621005
Distance46


GET Evidence
PADI4-R131T
aa_change Arg131Thr
aa_change_short R131T
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0165458
summary