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rs12762549

From SNPedia

Orientationplus
Stabilizedplus
Make rs12762549(C;C)
Make rs12762549(C;G)
Make rs12762549(G;G)
ReferenceGRCh38 38.1/142
Chromosome10
Position99861014
is asnp
is mentioned by
dbSNPrs12762549
ebirs12762549
HLIrs12762549
Exacrs12762549
Varsomers12762549
Maprs12762549
PheGenIrs12762549
hapmaprs12762549
1000 genomesrs12762549
hgdprs12762549
ensemblrs12762549
gopubmedrs12762549
geneviewrs12762549
scholarrs12762549
googlers12762549
pharmgkbrs12762549
gwascentralrs12762549
openSNPrs12762549
23andMers12762549
23andMe allrs12762549
SNP Nexus

SNPshotrs12762549
SNPdbers12762549
MSV3drs12762549
GWAS Ctlgrs12762549
GMAF0.4848
Max Magnitude
? (C;C) (C;G) (G;G) 28
[PMID 18294295] rs12762549 and rs11045585 can be used to predict whether docetaxel will induced leukopenia/neutropenia, according to a study of ~100 Japanese patients. When patients were classified into three groups by the scoring system based on the genotypes of these two SNPs, patients with a score of 1 or 2 were shown to have a significantly higher risk of docetaxel-induced leukopenia/neutropenia as compared to those with a score of 0 (P = 0.0000057; odds ratio [OR], 7.00; 95% CI [confidence interval], 2.95-16.59). This prediction system correctly classified 69.2% of severe leukopenia/neutropenia and 75.7% of non-leukopenia/neutropenia into the respective categories.




[PMID 22407408] Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals.


GET Evidence
rs12762549
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.507812
summary



[PMID 25648089OA-icon.png] Genetic Variations of Drug Transporters Can Influence on Drug Response in Patients Treated with Docetaxel Chemotherapy