From SNPedia
[
PMID 18294295]
rs12762549 and
rs11045585 can be used to predict whether
docetaxel will induced leukopenia/neutropenia, according to a study of ~100 Japanese patients. When patients were classified into three groups by the scoring system based on the genotypes of these two SNPs, patients with a score of 1 or 2 were shown to have a significantly higher risk of docetaxel-induced leukopenia/neutropenia as compared to those with a score of 0 (P = 0.0000057; odds ratio [OR], 7.00; 95% CI [confidence interval], 2.95-16.59). This prediction system correctly classified 69.2% of severe leukopenia/neutropenia and 75.7% of non-leukopenia/neutropenia into the respective categories.
| ? | (C;C) (C;G) (G;G) |
|---|
 |
| PharmGKB | PA162191294 |
| Name | |
| Annotation | A case-control association study in 84 patients who received docetaxel chemotherapy found a significant association of rs12762549 in ABCC2 with docetaxel-induced leukopenia/neutropenia. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:18294295 |
| Drugs | docetaxel |
| Diseases | Leukopenia, Neutropenia |
| Curation Level | Curated |
