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rs12777823

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 3.5 Avoid Plavix, higher risk for adverse cardiovascular events. CYP2C19 poor metabolizer.
(A;G) 2.5 Avoid Plavix, higher risk for adverse cardiovascular events.
(G;G) 0 common in clinvar
ReferenceGRCh38 38.1/142
Chromosome10
Position94645745
GeneLOC100130970
is asnp
is mentioned by
dbSNPrs12777823
ebirs12777823
HLIrs12777823
Exacrs12777823
Varsomers12777823
Maprs12777823
PheGenIrs12777823
hapmaprs12777823
1000 genomesrs12777823
hgdprs12777823
ensemblrs12777823
gopubmedrs12777823
geneviewrs12777823
scholarrs12777823
googlers12777823
pharmgkbrs12777823
gwascentralrs12777823
openSNPrs12777823
23andMers12777823
23andMe allrs12777823
SNP Nexus

SNPshotrs12777823
SNPdbers12777823
MSV3drs12777823
GWAS Ctlgrs12777823
GMAF0.2213
Max Magnitude3.5
? (A;A) (A;G) (G;G) 28
JAMA rs12777823 and rs4244285 implicated in platelet response to clopidogrel

[PMID 19706858OA-icon.png] Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy



GET Evidence
rs12777823
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.203125
summary



[PMID 23755828OA-icon.png] Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study


ClinVar
Risk rs12777823(A;A)
Alt rs12777823(A;A)
Reference rs12777823(G;G)
Significance Drug-response
Disease warfarin response - Dosage
Variation info
Gene
CLNDBN warfarin response - Dosage
Reversed 0
HGVS NC_000010.10:g.96405502G>A
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211190.1,