|(G;T)||1.5||slightly increased (1.2x) risk for vitamin D insufficiency|
|(T;T)||1.8||slightly increased (1.4x) risk for vitamin D insufficiency|
rs12785878, located near the 7-dehydrocholesterol reductase DHCR7 gene on chromosome 11q12, has been linked by several studies to vitamin D serum concentrations.
In both studies, the allele associated with lower vitamin D, and thus the potential for vitamin D insufficiency, is rs12785878(G). Carriers of two such alleles have lower vitamin D than carriers of one allele, who in turn on average have lower vitamin D levels than rs12785878(T;T) individuals.10.1016/S0140-6736(10)60588-0
A near-perfect proxy (i.e. substitute) for rs12785878 appears to be rs7944926.
|Trait||Vitamin D insufficiency|
|Title||Common genetic determinants of vitamin D insufficiency: a genome-wide association study.|
|Odds Ratio||None None|
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