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rs12807809

From SNPedia

Orientationplus
Stabilizedplus
Make rs12807809(C;C)
Make rs12807809(C;T)
Make rs12807809(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position124736389
is asnp
is mentioned by
dbSNPrs12807809
ebirs12807809
HLIrs12807809
Exacrs12807809
Varsomers12807809
Maprs12807809
PheGenIrs12807809
hapmaprs12807809
1000 genomesrs12807809
hgdprs12807809
ensemblrs12807809
gopubmedrs12807809
geneviewrs12807809
scholarrs12807809
googlers12807809
pharmgkbrs12807809
gwascentralrs12807809
openSNPrs12807809
23andMers12807809
23andMe allrs12807809
SNP Nexus

SNPshotrs12807809
SNPdbers12807809
MSV3drs12807809
GWAS Ctlgrs12807809
GMAF0.213
Max Magnitude
? (C;C) (C;T) (T;T) 28
23andMe blog schizophrenia
  • rs3131296(C) increased the odds of schizophrenia by 1.19x
  • rs12807809(T) increased the odds of schizophrenia by 1.15x
  • rs9960767(C) increased the odds of schizophrenia by 1.23 times.

[PMID 20673877] Although several of the SNPs reported in [PMID 19571808OA-icon.png] to be associated with increased risk for schizophrenia were replicated in this study of Han Chinese, rs12807809 did not (i.e. it was not found to be associated with increased risk in this study of ~2,500 Chinese patients).

GWAS snp
PMID [PMID 19571808OA-icon.png]
Trait Schizophrenia
Title Common variants conferring risk of schizophrenia
Risk Allele T
P-val 2E-9
Odds Ratio 1.15 [NR]
OMIM181500
Desc
Variant
Relatedalso


[PMID 21538840] Analysis of neurogranin (NRGN) in schizophrenia


[PMID 22461181] Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis


[PMID 22253779OA-icon.png] Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia

[PMID 20485477OA-icon.png] New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?

[PMID 21112188] A neuropsychological investigation of the genome wide associated schizophrenia risk variant NRGN rs12807809.

[PMID 22306195] Genetic and functional analysis of the gene encoding neurogranin in schizophrenia.


GET Evidence
rs12807809
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.226562
summary



[PMID 24386483OA-icon.png] Effects of the Neurogranin Variant rs12807809 on Thalamocortical Morphology in Schizophrenia


[PMID 21799211OA-icon.png] The effect of neurogranin on neural correlates of episodic memory encoding and retrieval.


[PMID 22005930OA-icon.png] Genome-wide association study of Alzheimer's disease with psychotic symptoms.


[PMID 24098564OA-icon.png] The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function


[PMID 25739323] Influence of NRGN rs12807809 polymorphism on symptom severity in individuals with schizophrenia in the Han population but not the Zhuang population of south China