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rs12916

From SNPedia

Orientationplus
Stabilizedplus
Make rs12916(C;C)
Make rs12916(C;T)
Make rs12916(T;T)
ReferenceGRCh38 38.1/141
Chromosome5
Position75360714
GeneHMGCR
is asnp
is mentioned by
dbSNPrs12916
ebirs12916
HLIrs12916
Exacrs12916
Varsomers12916
Maprs12916
PheGenIrs12916
hapmaprs12916
1000 genomesrs12916
hgdprs12916
ensemblrs12916
gopubmedrs12916
geneviewrs12916
scholarrs12916
googlers12916
pharmgkbrs12916
gwascentralrs12916
openSNPrs12916
23andMers12916
23andMe allrs12916
SNP Nexus

SNPshotrs12916
SNPdbers12916
MSV3drs12916
GWAS Ctlgrs12916
GMAF0.4096
Max Magnitude
? (C;C) (C;T) (T;T) 28

[PMID 20235787] Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins

GWAS snp
PMID [PMID 20864672OA-icon.png]
Trait
Title Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
Risk Allele T
P-val 1E-11
Odds Ratio 0.02 [0.01-0.03] unit decrease
OMIM142910
Desc
Variant
Relatedalso
GWAS snp
PMID [PMID 20686565OA-icon.png]
Trait
Title Biological, clinical and population relevance of 95 loci for blood lipids.
Risk Allele C
P-val 5.6E-45
Odds Ratio 2.4500 None


[PMID 19682379OA-icon.png] TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population.


[PMID 19913121OA-icon.png] Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.


[PMID 20578904] Common variants of HMGCR, CETP, APOAI, ABCB1, CYP3A4, and CYP7A1 genes as predictors of lipid-lowering response to atorvastatin therapy.

http://www.medscape.com/viewarticle/832327 Each additional allele of rs17238484(G) was associated with a mean 0.06-mmol/L lower LDL-cholesterol level. Similar reductions were associated with rs12916 SNP. In addition, they found that each additional allele of rs17238484-G was associated with a higher body weight (0.30 kg), waist circumference (0.32 cm), and plasma insulin concentration (1.62%) and plasma glucose concentration (0.23%). Again, the rs12916 SNP had similar effect

GWAS snp
PMID [PMID 24097068OA-icon.png]
Trait Cholesterol, total
Title Discovery and refinement of loci associated with lipid levels.
Risk Allele C
P-val 5E-74
Odds Ratio .68 [NR] unit increase


[PMID 25262344OA-icon.png] HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials