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rs12917

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common in complete genomics
Make rs12917(C;T)
Make rs12917(T;T)
ReferenceGRCh38 38.1/142
Chromosome10
Position129708019
GeneMGMT
is asnp
is mentioned by
dbSNPrs12917
ebirs12917
HLIrs12917
Exacrs12917
Varsomers12917
Maprs12917
PheGenIrs12917
hapmaprs12917
1000 genomesrs12917
hgdprs12917
ensemblrs12917
gopubmedrs12917
geneviewrs12917
scholarrs12917
googlers12917
pharmgkbrs12917
gwascentralrs12917
openSNPrs12917
23andMers12917
23andMe allrs12917
SNP Nexus

SNPshotrs12917
SNPdbers12917
MSV3drs12917
GWAS Ctlgrs12917
GMAF0.1506
Max Magnitude0
? (C;C) (C;T) (T;T) 28

[PMID 21075068] SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study


[PMID 20938339] Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients


[PMID 16385451OA-icon.png] A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.


[PMID 16857995OA-icon.png] Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.


[PMID 17119116OA-icon.png] Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study.


[PMID 17267408OA-icon.png] Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells.


[PMID 17482892OA-icon.png] Human variants of O6-alkylguanine-DNA alkyltransferase.


[PMID 18191955OA-icon.png] Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.


[PMID 18547414OA-icon.png] Genotyping panel for assessing response to cancer chemotherapy.


[PMID 18708406OA-icon.png] Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China.


[PMID 18990748OA-icon.png] International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.


[PMID 19124499OA-icon.png] Association and interactions between DNA repair gene polymorphisms and adult glioma.


[PMID 19318434OA-icon.png] Associations between polymorphisms in DNA repair genes and glioblastoma.


[PMID 19438866OA-icon.png] Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.


[PMID 19536092OA-icon.png] Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.


[PMID 21926110OA-icon.png] Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa.


[PMID 22430443OA-icon.png] Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma.


GET Evidence
MGMT-L84F
aa_change Leu84Phe
aa_change_short L84F
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.195312
summary



[PMID 24084248] The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes


[PMID 24500421OA-icon.png] Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis


[PMID 24552298OA-icon.png] Association Between Six Genetic Polymorphisms and Colorectal Cancer: A Meta-Analysis