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ReferenceGRCh38 38.1/142
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1000 genomesrs1295686
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SNP Nexus

GWAS Ctlgrs1295686
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 20860503OA-icon.png]
Title A large-scale, consortium-based genomewide association study of asthma
Risk Allele T
P-val 1E-7
Odds Ratio 1.15 [1.09-1.20]

[PMID 21050946OA-icon.png] Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgE

[PMID 22515947OA-icon.png] Associations Between Pro- and Anti-Inflammatory Cytokine Genes and Breast Pain in Women Prior to Breast Cancer Surgery

[PMID 22075330OA-icon.png] A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study

[PMID 15660293OA-icon.png] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.

[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16449530OA-icon.png] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

[PMID 17303794OA-icon.png] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.

[PMID 17346294OA-icon.png] IL13 gene polymorphism association with cord serum immunoglobulin E.

[PMID 18056382OA-icon.png] Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.

[PMID 18186920OA-icon.png] IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.

[PMID 18410415OA-icon.png] Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood.

[PMID 18625055OA-icon.png] Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.

[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18687755OA-icon.png] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.

[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19956101OA-icon.png] Overview of the Rapid Response data.

[PMID 19956102OA-icon.png] Evidence for association of the TCF7 locus with type I diabetes.

[PMID 19956109OA-icon.png] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

[PMID 20015396OA-icon.png] Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.

[PMID 20403202OA-icon.png] Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study.

[PMID 21111021] Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.

[PMID 21320344OA-icon.png] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

GWAS snp
PMID [PMID 23042114]
Trait Atopic dermatitis
Title Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
Risk Allele T
P-val 2E-6
Odds Ratio 1.22 [NR]

[PMID 23841068OA-icon.png] Interleukin-13 +1923C/T Polymorphism Is Associated with Asthma Risk: A Meta-Analysis

GWAS snp
PMID [PMID 23886662OA-icon.png]
Trait Atopic dermatitis
Title A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.
Risk Allele A
P-val 2E-17
Odds Ratio 1.38 [1.283-1.49]

[PMID 23028483OA-icon.png] Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.

GWAS snp
PMID [PMID 24241537]
Trait Asthma (childhood, severe)
Title A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
Risk Allele T
P-val 2E-6
Odds Ratio 1.31 [1.17-1.48]

[PMID 26365633] Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese