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rs12980275

From SNPedia

Orientationplus
Stabilizedplus
Make rs12980275(A;A)
Make rs12980275(A;G)
Make rs12980275(G;G)
ReferenceGRCh38 38.1/141
Chromosome19
Position39241143
is asnp
is mentioned by
dbSNPrs12980275
ebirs12980275
HLIrs12980275
Exacrs12980275
Varsomers12980275
Maprs12980275
PheGenIrs12980275
hapmaprs12980275
1000 genomesrs12980275
hgdprs12980275
ensemblrs12980275
gopubmedrs12980275
geneviewrs12980275
scholarrs12980275
googlers12980275
pharmgkbrs12980275
gwascentralrs12980275
openSNPrs12980275
23andMers12980275
23andMe allrs12980275
SNP Nexus

SNPshotrs12980275
SNPdbers12980275
MSV3drs12980275
GWAS Ctlgrs12980275
GMAF0.314
Max Magnitude
? (A;A) (A;G) (G;G) 28
23andMe blog

rs8099917(C) less likely to respond to Hepatitis C treatment.

rs12979860(C;C) better able to become naturally Hepatitis C virus-free. rs12980275(A) usually corresponds to the rs12979860(C)


[PMID 19749757] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C

OMIM607402
DescINTERLEUKIN 28B; IL28B
Variant
Relatedalso


OMIM609532
Desc
Variant
Relatedalso
[PMID 21390311OA-icon.png] Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms


[PMID 21987611OA-icon.png] IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients


[PMID 22118055] Single and combined IL28B, ITPA and SLC28A3 host genetic markers modulating response to anti-hepatitis C therapy


[PMID 22234924] Combined effects of different IL28B gene variants on the outcome of dual combination therapy in chronic HCV type 1 infection


[PMID 22253715OA-icon.png] Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3


[PMID 22108195] Polymorphisms near IL28B and serologic response to peginterferon in HBeAg-positive patients with chronic hepatitis B


[PMID 22649509OA-icon.png] IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population


[PMID 22329371] IL28B genetic variants and gender are associated with spontaneous clearance of hepatitis C virus infection

GWAS snp
PMID [PMID 22497812OA-icon.png]
Trait
Title Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response.
Risk Allele
P-val 5E-17
Odds Ratio None None

[PMID 20708617] Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C.

[PMID 21112657] Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients.

[PMID 21112660] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.

[PMID 21274371OA-icon.png] Peginterferon and ribavirin treatment for hepatitis C virus infection.

[PMID 21354446] IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C.

[PMID 21443535] IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C.

[PMID 22310928] Genetic variation in IL28B is associated with the development of hepatitis B-related hepatocellular carcinoma.


GET Evidence
rs12980275
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.357143
summary



[PMID 23103287] IL28B polymorphisms are associated with severity of liver disease in human immunodeficiency virus (HIV) patients coinfected with hepatitis C virus.


[PMID 23135173] Analysis of IL28B alleles with virologic response patterns and plasma cytokine levels in HIV/HCV-coinfected patients.


[PMID 23314745OA-icon.png] Impact of IL-28B polymorphisms on pegylated interferon plus ribavirin treatment response in children and adolescents infected with HCV genotypes 1 and 4.


[PMID 23565619] IL28RA polymorphism is associated with early hepatitis C virus (HCV) treatment failure in human immunodeficiency virus-/HCV-coinfected patients.


[PMID 24999753] Interleukin 28B Polymorphisms and Therapy Response in Egyptian Hepatitis C Genotype-4 Patients


[PMID 25032184OA-icon.png] No association between the IL28B SNP and response to peginterferon plus ribavirin combination treatment in Korean chronic hepatitis C patients


[PMID 25652367] IL28B rs12980275 polymorphism shows association with response to treatment in Pakistani patients with Chronic Hepatitis C


[PMID 25769643] IL28B rs12980275 variant as a predictor of sustained virologic response to pegylated-interferon and ribavirin in chronic hepatitis C patients: A systematic review and meta-analysis


[PMID 24118788] Genetic variation in interleukin 28B and correlation with chronic hepatitis B virus infection in Saudi Arabian patients


[PMID 24924923] The relationship between IL-28B polymorphisms and the response to peginterferon alfa-2a monotherapy in anti-HBe-positive patients with chronic HBV infection


[PMID 25938745] IL28B polymorphisms of both recipient and donor cooperate to influence IFN treatment response in HCV recurrence after liver transplantation, but IL28B SNPs of the recipient play a major role in IFN-induced blocking of HCV replication


[PMID 25663241] Genetic Variants in Interleukin-28B Are Associated with Diabetes and Diabetes-Related Complications in Patients with Chronic Hepatitis C Virus Infection


[PMID 25661337] Role of pharmacogenetic in ribavirin outcome prediction and pharmacokinetics in an Italian cohort of HCV-1 and 4 patients


[PMID 24840315] Interleukin-28 gene polymorphisms may contribute to HBsAg persistence and the development of HBeAg-negative chronic hepatitis B


[PMID 26740868] Prevalence of Hepatitis C among Egyptian Children with Sickle Cell Disease and the Role of IL28b Gene Polymorphisms in Spontaneous Viral Clearance.