Have questions? Visit https://www.reddit.com/r/SNPedia

rs13207033

From SNPedia

(A;A) appears protective against rheumatoid arthritis
Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 reduced risk of rheumatoid arthritis
(A;G) None
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome6
Position137644281
is asnp
is mentioned by
dbSNPrs13207033
ebirs13207033
HLIrs13207033
Exacrs13207033
Varsomers13207033
Maprs13207033
PheGenIrs13207033
hapmaprs13207033
1000 genomesrs13207033
hgdprs13207033
ensemblrs13207033
gopubmedrs13207033
geneviewrs13207033
scholarrs13207033
googlers13207033
pharmgkbrs13207033
gwascentralrs13207033
openSNPrs13207033
23andMers13207033
23andMe allrs13207033
SNP Nexus

SNPshotrs13207033
SNPdbers13207033
MSV3drs13207033
GWAS Ctlgrs13207033
GMAF0.1905
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs13207033 can be considered a proxy for rs10499194, since it is perfectly correlated to it (r2 =1). In WTCCC data, the minor allele of rs13207033 was seen to be less frequent in patients with rheumatoid arthritis than in controls, just as rs10499194 has been seen in other studies.[PMID 17982456OA-icon.png]

[PMID 19417005OA-icon.png] rheumatoid arthritis

  • rs6920220 [P= 2.6 x 10(-6), OR 1.22 (1.13-1.33)].
  • rs5029937
  • rs13207033 protective [P= 0.0001, OR 0.86 (0.8-0.93)] perfectly correlated with rs10499194

The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared to carriage of none [OR of 1.86 (95% CI) (1.51-2.29)]. This equates to an effect size of 1.50 (95% CI 1.21-1.85)


[PMID 19292917OA-icon.png] Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility

OMIM180300
Desc
Variant
Relatedalso
[PMID 19674979OA-icon.png] Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.


[PMID 20444755OA-icon.png] Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.


[PMID 22328738OA-icon.png] Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.


[PMID 22798268] Rheumatoid arthritis-associated polymorphisms at 6q23 are associated with radiological damage in autoantibody-positive RA.