|(A;A) appears protective against rheumatoid arthritis|rs13207033
|?|| (A;A) (A;G) (G;G) ||28|
can be considered a proxy for rs10499194
, since it is perfectly correlated to it (r2
=1). In WTCCC data, the minor allele of rs13207033
was seen to be less frequent in patients with rheumatoid arthritis
than in controls, just as rs10499194
has been seen in other studies.[PMID 17982456
[PMID 19417005] rheumatoid arthritis
- rs6920220 [P= 2.6 x 10(-6), OR 1.22 (1.13-1.33)].
- rs13207033 protective [P= 0.0001, OR 0.86 (0.8-0.93)] perfectly correlated with rs10499194
The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared to carriage of none [OR of 1.86 (95% CI) (1.51-2.29)]. This equates to an effect size of 1.50 (95% CI 1.21-1.85)
[PMID 19292917] Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility
] Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.
[PMID 20444755] Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
[PMID 22328738] Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
[PMID 22798268] Rheumatoid arthritis-associated polymorphisms at 6q23 are associated with radiological damage in autoantibody-positive RA.