|(C;C)||2.6||2.6x increased risk for Crohn's disease|
|(C;T)||1.3||1.3x increased risk for Crohn's disease|
A study including 557 Crohn's disease (CD) patients, 425 ulcerative colitis (UC) patients, and 672 ethnically matched Spanish controls as well as a meta-analysis concluded that rs13361189(C) was associated with CD (p=1.07 x 10(-19), pooled odds ratio 1.34) and UC (p=0.0069, pooled odds ratio 1.16).[PMID 19491842]
[PMID 19953089] Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
[PMID 22713085] IRGM gene polymorphisms and risk of gastric cancer
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18580884] Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort.
[PMID 19140132] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
[PMID 19165925] Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
[PMID 19750224] Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.
[PMID 20106866] Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.
[PMID 20395867] Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?
[PMID 21049557] NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 22065112] The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 24232856] Association between Variants of the Autophagy Related Gene - IRGM and Susceptibility to Crohn's Disease and Ulcerative Colitis: A Meta-Analysis
[PMID 24264476] Autophagy Gene Polymorphism is Associated with Susceptibility to Leprosy by Affecting Inflammatory Cytokines
[PMID 22573572] Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II).
[PMID 24859836] Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions
[PMID 25009628] IRGM rs13361189 polymorphism may contribute to susceptibility to Crohn's disease: A meta-analysis
[PMID 26066377] Autophagy and inflammatory bowel disease: Association between variants of the autophagy-related IRGM gene and susceptibility to Crohn's disease