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rs135745

From SNPedia

Orientationplus
Stabilizedplus
Make rs135745(C;C)
Make rs135745(C;G)
Make rs135745(G;G)
ReferenceGRCh38 38.1/141
Chromosome22
Position38287631
is asnp
is mentioned by
dbSNPrs135745
ebirs135745
HLIrs135745
Exacrs135745
Varsomers135745
Maprs135745
PheGenIrs135745
hapmaprs135745
1000 genomesrs135745
hgdprs135745
ensemblrs135745
gopubmedrs135745
geneviewrs135745
scholarrs135745
googlers135745
pharmgkbrs135745
gwascentralrs135745
openSNPrs135745
23andMers135745
23andMe allrs135745
SNP Nexus

SNPshotrs135745
SNPdbers135745
MSV3drs135745
GWAS Ctlgrs135745
GMAF0.4132
Max Magnitude
? (C;C) (C;G) (G;G) 28
This SNP, located in the 3' UTR of the CSNK1E gene, has been associated with sensitivity to the acute effects of d-amphetamine. Sensitivity to psychoactive drugs has been associated with potential to develop drug abuse. The more sensitive allele is rs135745(C). [PMID 16237383]

However, in a separate study, this SNP did not affect susceptibility to methamphetamine dependence or psychosis, at least in a Japanese population.[PMID 18991847]

Note: orientation relative to dbSNP needs to be confirmed/checked.


[PMID 18518925OA-icon.png] Genetic susceptibility to heroin addiction: a candidate gene association study.


[PMID 19050854OA-icon.png] A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.


[PMID 20174623OA-icon.png] Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.


[PMID 22367616] Association between a casein kinase 1 epsilon gene polymorphism and schizophrenia in a Chinese Han population.


[PMID 22113361] No association of a casein kinase 1epsilon (CK1epsilon) gene polymorphism with personality traits in healthy Chinese-Han subjects.