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rs1375144

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 1.5 1.59x increased risk of developing bipolar disorder (one study)
(C;T) 1.3 1.32x increased risk of developing bipolar disorder (one study)
(G;G) 0
(T;T) 1 Normal risk of developing bipolar disorder
ReferenceGRCh38 38.1/141
Chromosome2
Position115483610
GeneDPP10
is asnp
is mentioned by
dbSNPrs1375144
ebirs1375144
HLIrs1375144
Exacrs1375144
Varsomers1375144
Maprs1375144
PheGenIrs1375144
hapmaprs1375144
1000 genomesrs1375144
hgdprs1375144
ensemblrs1375144
gopubmedrs1375144
geneviewrs1375144
scholarrs1375144
googlers1375144
pharmgkbrs1375144
gwascentralrs1375144
openSNPrs1375144
23andMers1375144
23andMe allrs1375144
SNP Nexus

SNPshotrs1375144
SNPdbers1375144
MSV3drs1375144
GWAS Ctlgrs1375144
GMAF0.4853
Max Magnitude1.5
? (C;C) (C;T) (T;T) 28
rs1375144, a SNP in the DPP10 gene, has been reported in a large study to be associated with bipolar disorder.


The risk allele (oriented to the dbSNP entry) is (C) ; the odds ratio associated with heterozygotes is 1.32 (CI 1.07-1.63), and for homozygotes, 1.59 (CI 1.29-1.96). [Note: the 2009 citation below did not see a statistically significant difference between cases and controls for this allele in their study.][PMID 17554300OA-icon.png]

GWAS snp
PMID [PMID 21254220OA-icon.png]
Trait
Title Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
Risk Allele
P-val 0.000002
Odds Ratio None None

[PMID 19308021OA-icon.png] Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.