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rs1376251

From SNPedia

Orientationplus
Stabilizedplus
Make rs1376251(C;C)
Make rs1376251(C;T)
Make rs1376251(T;T)
ReferenceGRCh37.p2 37.2/134
Chromosome12
Position11138852
GenePRH1, PRR4, TAS2R50
is asnp
is mentioned by
dbSNPrs1376251
ebirs1376251
HLIrs1376251
Exacrs1376251
Varsomers1376251
Maprs1376251
PheGenIrs1376251
hapmaprs1376251
1000 genomesrs1376251
hgdprs1376251
ensemblrs1376251
gopubmedrs1376251
geneviewrs1376251
scholarrs1376251
googlers1376251
pharmgkbrs1376251
gwascentralrs1376251
openSNPrs1376251
23andMers1376251
23andMe allrs1376251
SNP Nexus

SNPshotrs1376251
SNPdbers1376251
MSV3drs1376251
GWAS Ctlgrs1376251
GMAF0.3981
Max Magnitude
? (C;C) (C;T) (T;T) 28

rs1376251 increases susceptibility to Myocardial Infarction 1.23 times for heterozygotes (CT) and 1.58 times for homozygotes (CC) [PMID 16175505OA-icon.png]

An independent study of 3657 patients with myocardial infarction (885 women and 2772 men) and 1211 control individuals (598 women and 613 men) did not observe any correlation to this SNP.[PMID 19709766]


[PMID 22192511] KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly


[PMID 22856164] [Evaluation of association between 9 genetic polymorphism and myocardial infarction in the Siberian population]


[PMID 18599554OA-icon.png] Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.


[PMID 19092995OA-icon.png] Bitter taste receptors influence glucose homeostasis.


[PMID 19924713OA-icon.png] Use of longitudinal data in genetic studies in the genome-wide association studies era: summary of Group 14.


[PMID 20017983OA-icon.png] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.


GET Evidence
TAS2R50-C203Y
aa_change Cys203Tyr
aa_change_short C203Y
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.251999
summary



[PMID 24083639OA-icon.png] Variations in Bitter-Taste Receptor Genes, Dietary Intake, and Colorectal Adenoma Risk