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rs1378942

From SNPedia

Orientationminus
Stabilizedminus
Make rs1378942(G;G)
Make rs1378942(G;T)
Make rs1378942(T;T)
ReferenceGRCh38 38.1/141
Chromosome15
Position74785026
GeneCSK
is asnp
is mentioned by
dbSNPrs1378942
ebirs1378942
HLIrs1378942
Exacrs1378942
Varsomers1378942
Maprs1378942
PheGenIrs1378942
hapmaprs1378942
1000 genomesrs1378942
hgdprs1378942
ensemblrs1378942
gopubmedrs1378942
geneviewrs1378942
scholarrs1378942
googlers1378942
pharmgkbrs1378942
gwascentralrs1378942
openSNPrs1378942
23andMers1378942
23andMe allrs1378942
SNP Nexus

SNPshotrs1378942
SNPdbers1378942
MSV3drs1378942
GWAS Ctlgrs1378942
GMAF0.3301
Max Magnitude
? (G;G) (G;T) (T;T) 28

23andMe blog blood pressure

GWAS snp
PMID [PMID 19430483OA-icon.png]
Trait Diastolic Blood Pressure
Title Genome-wide association study identifies eight loci associated with blood pressure
Risk Allele C
P-val 1E-23
Odds Ratio 0.43 [0.35-0.51] mm Hg increase


[PMID 19960030] Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts


[PMID 20921432] Common Variants in the ATP2B1 Gene Are Associated With Susceptibility to Hypertension. The Japanese Millennium Genome Project

GWAS snp
PMID [PMID 21909115OA-icon.png]
Trait
Title Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Risk Allele C
P-val 3E-26
Odds Ratio 0.4160 [NR] mmHg increase
GWAS snp
PMID [PMID 21909110OA-icon.png]
Trait
Title Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Risk Allele C
P-val 2E-15
Odds Ratio 0.3860 [0.29-0.48] mmHg increase


[PMID 22492992] Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension.


[PMID 22525200] Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms.


GET Evidence
rs1378942
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.304688
summary



High Blood Pressure (Hypertension)


[PMID 23946333OA-icon.png] Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis


[PMID 24401815] Interaction between c-Src Tyrosine Kinase Gene Variant and Fish Oil Intake Influences Blood Pressure in Healthy Adults


[PMID 22959498] Recapitulation of four hypertension susceptibility genes (CSK, CYP17A1, MTHFR, and FGF5) in East Asians.


[PMID 23102448] Physical activity modifies the associations between genetic variants and hypertension in the Chinese children.


[PMID 23591986] Influence of obesity on association between genetic variants identified by genome-wide association studies and hypertension risk in Chinese children.