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rs1387153

From SNPedia

Orientationplus
Stabilizedplus
Make rs1387153(C;C)
Make rs1387153(C;T)
Make rs1387153(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position92940662
GeneMIR194-2
is asnp
is mentioned by
dbSNPrs1387153
ebirs1387153
HLIrs1387153
Exacrs1387153
Varsomers1387153
Maprs1387153
PheGenIrs1387153
hapmaprs1387153
1000 genomesrs1387153
hgdprs1387153
ensemblrs1387153
gopubmedrs1387153
geneviewrs1387153
scholarrs1387153
googlers1387153
pharmgkbrs1387153
gwascentralrs1387153
openSNPrs1387153
23andMers1387153
23andMe allrs1387153
SNP Nexus

SNPshotrs1387153
SNPdbers1387153
MSV3drs1387153
GWAS Ctlgrs1387153
GMAF0.3466
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 19060909]
Trait Fasting plasma glucose
Title A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
Risk Allele T
P-val 2E-36
Odds Ratio 0.07 [0.05-0.08] mmol/l increase


[PMID 19651812OA-icon.png] Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites



[PMID 20536959] Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort

GWAS snp
PMID [PMID 20581827OA-icon.png]
Trait Type 2 diabetes
Title Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Risk Allele T
P-val 8E-15
Odds Ratio 1.09 [1.06-1.11]

[PMID 20858683OA-icon.png] Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways

OMIM613233
Desc
Variant
Relatedalso
GWAS snp
PMID [PMID 21386085OA-icon.png]
Trait
Title A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
Risk Allele C
P-val 2E-9
Odds Ratio 0.2100 [0.15-0.27] unit decrease


[PMID 21658282OA-icon.png] Melatonin Receptor 1 B Polymorphisms associated with the risk of Gestational Diabetes Mellitus


[PMID 22450346] The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population


[PMID 22768333OA-icon.png] Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women


[PMID 19060907OA-icon.png] Variants in MTNR1B influence fasting glucose levels.


[PMID 19324940OA-icon.png] G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.


[PMID 19937311] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.


[PMID 20628598OA-icon.png] Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.


[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.


[PMID 21445555] Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data.


[PMID 21558052OA-icon.png] A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity.


GET Evidence
rs1387153
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.3125
summary



[PMID 23690305OA-icon.png] Genetic variants and the risk of gestational diabetes mellitus: a systematic review


[PMID 23560644] Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease.


[PMID 26563312] Relationship between melatonin receptor 1B (rs10830963 and rs1387153) with gestational diabetes mellitus: a case-control study and meta-analysis