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rs1414334

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 associated with metabolic syndrome when taking antipsychotics
Make rs1414334(C;G)
Make rs1414334(G;G)
ReferenceGRCh38 38.1/141
ChromosomeX
Position114903581
GeneHTR2C
is asnp
is mentioned by
dbSNPrs1414334
ebirs1414334
HLIrs1414334
Exacrs1414334
Varsomers1414334
Maprs1414334
PheGenIrs1414334
hapmaprs1414334
1000 genomesrs1414334
hgdprs1414334
ensemblrs1414334
gopubmedrs1414334
geneviewrs1414334
scholarrs1414334
googlers1414334
pharmgkbrs1414334
gwascentralrs1414334
openSNPrs1414334
23andMers1414334
23andMe allrs1414334
SNP Nexus

SNPshotrs1414334
SNPdbers1414334
MSV3drs1414334
GWAS Ctlgrs1414334
GMAF0.1856
Max Magnitude2
? (C;C) (C;G) (G;G) 28

[PMID 19142101] rs1414334(C) associated with the metabolic syndrome in patients using



[PMID 20680028] Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: a replication study


[PMID 21186965OA-icon.png] Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene


[PMID 21105285] Combined HTR2C-LEP genotype as a determinant of obesity in patients using antipsychotic medication


[PMID 17016522] The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study.


[PMID 17632216] The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia.


GET Evidence
rs1414334
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.663043
summary



ClinVar
Risk rs1414334(G;G)
Alt rs1414334(G;G)
Reference rs1414334(C;C)
Significance Drug-response
Disease risperidone response - Toxicity/ADR antipsychotics response - Toxicity/ADR clozapine response - Toxicity/ADR
Variation info
Gene HTR2C
CLNDBN risperidone response - Toxicity/ADR antipsychotics response - Toxicity/ADR clozapine response - Toxicity/ADR
Reversed 0
HGVS NC_000023.10:g.114138144C>G
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211204.1, RCV000211340.1, RCV000211420.1,