|| 1.94x increased breast cancer risk
|| 1.29x increased breast cancer risk
|?|| (A;A) (A;G) (G;G) ||28|
is a SNP reported to potentially represent a miR-125b binding site.
A study of 459 probands from a breast cancer affected sibling pair cohort were recruited from the ECOG study, and in conjunction with 1,145 patient samples from the CGEMS study, led to the conclusion that rs1434536 was associated with increased risk for breast cancer. The odds ratios for rs1434536(A;G) and (A;A) individuals were 1.29 (CI: 0.95-1.74) and 1.94 (CI: 1.40-2.71), respectively (p=1.6x10e-4).[PMID 19738052]
[PMID 21556765] A miR-125b binding site polymorphism in bone morphogenetic protein membrane receptor type IB gene and prostate cancer risk in China.