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rs1434536

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 2 1.94x increased breast cancer risk
(A;G) 1.3 1.29x increased breast cancer risk
(G;G) normal
ReferenceGRCh38 38.1/141
Chromosome4
Position95154814
GeneBMPR1B
is asnp
is mentioned by
dbSNPrs1434536
ebirs1434536
HLIrs1434536
Exacrs1434536
Varsomers1434536
Maprs1434536
PheGenIrs1434536
hapmaprs1434536
1000 genomesrs1434536
hgdprs1434536
ensemblrs1434536
gopubmedrs1434536
geneviewrs1434536
scholarrs1434536
googlers1434536
pharmgkbrs1434536
gwascentralrs1434536
openSNPrs1434536
23andMers1434536
23andMe allrs1434536
SNP Nexus

SNPshotrs1434536
SNPdbers1434536
MSV3drs1434536
GWAS Ctlgrs1434536
GMAF0.4307
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs1434536 is a SNP reported to potentially represent a miR-125b binding site.

A study of 459 probands from a breast cancer affected sibling pair cohort were recruited from the ECOG study, and in conjunction with 1,145 patient samples from the CGEMS study, led to the conclusion that rs1434536 was associated with increased risk for breast cancer. The odds ratios for rs1434536(A;G) and (A;A) individuals were 1.29 (CI: 0.95-1.74) and 1.94 (CI: 1.40-2.71), respectively (p=1.6x10e-4).[PMID 19738052OA-icon.png]

[PMID 21556765] A miR-125b binding site polymorphism in bone morphogenetic protein membrane receptor type IB gene and prostate cancer risk in China.