|rare variant associated with breast cancer risk|
|| ~3x higher breast cancer risk
, also known as c.5791C>T, p.Arg1931Ter and R1931X, is a SNP in the FANCM
Genotyping 8,635 familial breast cancer cases led to an association with rs144567652, (odds ratio 3.93, CI:1.28-12.11, p=0.017), and two subsequent meta-analyses showed similar [breast cancer]] associations (odds ratio 3.67, CI:1.04-12.87, p=0.043, and, OR of 3.33, CI:1.09-13.62, p=0.032), respectively.[PMID 26130695]
Note: a name used by 23andMe for this SNP is i6050899.