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rs1451371

From SNPedia

Orientationplus
Stabilizedplus
Make rs1451371(C;C)
Make rs1451371(C;T)
Make rs1451371(T;T)
ReferenceGRCh38 38.1/141
Chromosome7
Position50485353
GeneDDC
is asnp
is mentioned by
dbSNPrs1451371
ebirs1451371
HLIrs1451371
Exacrs1451371
Varsomers1451371
Maprs1451371
PheGenIrs1451371
hapmaprs1451371
1000 genomesrs1451371
hgdprs1451371
ensemblrs1451371
gopubmedrs1451371
geneviewrs1451371
scholarrs1451371
googlers1451371
pharmgkbrs1451371
gwascentralrs1451371
openSNPrs1451371
23andMers1451371
23andMe allrs1451371
SNP Nexus

SNPshotrs1451371
SNPdbers1451371
MSV3drs1451371
GWAS Ctlgrs1451371
GMAF0.4096
Max Magnitude
? (C;C) (C;T) (T;T) 28

per OMIM, Ma et al. (2005) [PMID 15879433] found two different DDC haplotypes associated with nicotine dependence in African Americans and European Americans (with measures of smoking quantity [SQ], heaviness of smoking index [HSI], and the Fagerstrom test for ND [FTND])

  • in African Americans, rs921451(T), rs3735273(G), rs1451371(T), rs2060762(G), all three measures sig. associated after correction for multiple testing
  • in European Americans, rs921451(T), rs3735273(G), rs1451371(T), rs3757472(G), which showed a sig. assoc. w/ the SQ and FTND score


[PMID 19221445] Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits

OMIM188890
DescTOBACCO Addiction, SUSCEPTIBILITY TO
Variant
Relatedalso
OMIM107930
DescDOPA DECARBOXYLASE; DDC
Variant
Relatedalso



[PMID 17184203] DOPA decarboxylase gene is associated with nicotine dependence.


[PMID 17948905] Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior.


GET Evidence
rs1451371
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.403226
summary