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rs145518263

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0 common


Make rs145518263(C;C)
ReferenceGRCh38 38.1/141
Chromosome15
Position58665141
GeneADAM10
is asnp
is mentioned by
dbSNPrs145518263
ebirs145518263
HLIrs145518263
Exacrs145518263
Varsomers145518263
Maprs145518263
PheGenIrs145518263
hapmaprs145518263
1000 genomesrs145518263
hgdprs145518263
ensemblrs145518263
gopubmedrs145518263
geneviewrs145518263
scholarrs145518263
googlers145518263
pharmgkbrs145518263
gwascentralrs145518263
openSNPrs145518263
23andMers145518263
23andMe allrs145518263
SNP Nexus

SNPshotrs145518263
SNPdbers145518263
MSV3drs145518263
GWAS Ctlgrs145518263
Max Magnitude0
rs145518263, also known as R181G or Arg181Gly, is a SNP in the ADAM metallopeptidase domain 10 ADAM10 gene. The common allele is rs145518263(T), encoding the Arg.

[PMID 19608551OA-icon.png] The rs145518263(C) allele was found in 11 of 16 individuals affected by Alzheimer's disease (average onset age 69.5 years) from seven late-onset AD families. This mutation was also found in at least one unaffected subject, implying incomplete penetrance.

This SNP is referred to as i6006817 by 23andMe.


ClinVar
Risk rs145518263(C;C)
Alt rs145518263(C;C)
Reference rs145518263(T;T)
Significance Other
Disease Alzheimer disease 18
Variation info
Gene ADAM10
CLNDBN Alzheimer disease 18
Reversed 0
HGVS NC_000015.9:g.58957340T>C
CLNSRC OMIM Allelic Variant
CLNACC RCV000077798.2,