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rs1466785

From SNPedia

Orientationplus
Stabilizedplus
Make rs1466785(C;C)
Make rs1466785(C;T)
Make rs1466785(T;T)
ReferenceGRCh38 38.1/141
Chromosome8
Position11765947
is asnp
is mentioned by
dbSNPrs1466785
ebirs1466785
HLIrs1466785
Exacrs1466785
Varsomers1466785
Maprs1466785
PheGenIrs1466785
hapmaprs1466785
1000 genomesrs1466785
hgdprs1466785
ensemblrs1466785
gopubmedrs1466785
geneviewrs1466785
scholarrs1466785
googlers1466785
pharmgkbrs1466785
gwascentralrs1466785
openSNPrs1466785
23andMers1466785
23andMe allrs1466785
SNP Nexus

SNPshotrs1466785
SNPdbers1466785
MSV3drs1466785
GWAS Ctlgrs1466785
GMAF0.3857
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 24698998OA-icon.png]
Trait Breast cancer
Title DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
Risk Allele T
P-val 2.7E-3
Odds Ratio 1.09 [1.03-1.16]

Minor allele increases risk of breast cancer in BRCA2 mutation carriers in a study size of 23,463 carriers[PMID 24698998OA-icon.png]. The study considers rs804276 and rs804271 more likely causal variants, but they're not tested by standard beadchips. All are thought to affect NEIL2, which removes oxidized bases from transcribing genes.

[PMID 21169365OA-icon.png] Preferential repair of oxidized base damage in the transcribed genes of mammalian cells


[PMID 21945496] Look beyond one's own nose: combination of information from publicly available sources reveals an association of GATA4 polymorphisms with plasma triglycerides