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rs1467558

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) 0 common on affy axiom data
Make rs1467558(A;A)
Make rs1467558(A;G)
ReferenceGRCh38 38.1/142
Chromosome11
Position35208126
GeneCD44
is asnp
is mentioned by
dbSNPrs1467558
ebirs1467558
HLIrs1467558
Exacrs1467558
Varsomers1467558
Maprs1467558
PheGenIrs1467558
hapmaprs1467558
1000 genomesrs1467558
hgdprs1467558
ensemblrs1467558
gopubmedrs1467558
geneviewrs1467558
scholarrs1467558
googlers1467558
pharmgkbrs1467558
gwascentralrs1467558
openSNPrs1467558
23andMers1467558
23andMe allrs1467558
SNP Nexus

SNPshotrs1467558
SNPdbers1467558
MSV3drs1467558
GWAS Ctlgrs1467558
GMAF0.08356
Max Magnitude0
? (A;A) (A;G) (G;G) 28
[PMID 19416960OA-icon.png] After taking Acetaminophen (Tylenol®), rs1467558(A;G) individuals have higher alanine aminotransferase (ALT) levels, a sign of liver toxicity, than do (G;G) homozygotes. More studies are needed; there was only 1 (A;A) individual, and he didn't show elevated ALT levels; furthermore, the ALT increases were "modest" anyway for (A;G) individuals compared to (G;G). see also: 23andMe blog

Note: the orientation of this SNP in SNPedia is as detailed in dbSNP, but in publications (including 23andMe's blog) the orientation is 'flipped', so what's (A;A) in dbSNP is (T;T) as discussed by the 23andMe blog.


[PMID 17903303OA-icon.png] Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.


[PMID 18194558OA-icon.png] A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.


GET Evidence
CD44-I479T
aa_change Ile479Thr
aa_change_short I479T
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.862986
summary