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rs1470579

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;C) 1.2x increased risk for type-2 diabetes
(C;C) 1.2x increased risk for type-2 diabetes
ReferenceGRCh38 38.1/141
Chromosome3
Position185811292
GeneIGF2BP2
is asnp
is mentioned by
dbSNPrs1470579
ebirs1470579
HLIrs1470579
Exacrs1470579
Varsomers1470579
Maprs1470579
PheGenIrs1470579
hapmaprs1470579
1000 genomesrs1470579
hgdprs1470579
ensemblrs1470579
gopubmedrs1470579
geneviewrs1470579
scholarrs1470579
googlers1470579
pharmgkbrs1470579
gwascentralrs1470579
openSNPrs1470579
23andMers1470579
23andMe allrs1470579
SNP Nexus

SNPshotrs1470579
SNPdbers1470579
MSV3drs1470579
GWAS Ctlgrs1470579
GMAF0.4123
Max Magnitude0
? (A;A) (A;C) (C;C) 28

[PMID 18477659] rs1470579 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.18 (CI: 1.07-1.31, p = 8.3 x 10e-4)

[PMID 18461161OA-icon.png] T2D and normal glucose tolerant (NGT) individuals. (3,295 T2D and 3,595 NGT), strong associations with T2D were found for

  • CDKAL1 (OR(rs7756992) = 1.30[1.19-1.42], P = 2.3x10(-9))
  • CDKN2A/2B (OR(rs10811661) = 0.74[0.66-0.82], P = 3.5x10(-8))
  • IGFBP2 (OR(rs1470579) = 1.17[1.07-1.27], P = 0.0003) SNPs.

T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 rs7903146 SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24)

[PMID 18430866OA-icon.png] Neither rs4402960 or rs1470579 were found to be associated with type-2 diabetes in a study of 3,000 French Caucasians.

[PMID 19033397OA-icon.png] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

Note: rs1470579 is fairly tightly linked (r2=0.87) with another IGF2BP2 gene SNP also associated with type-2 diabetes, rs4402960

GWAS snp
PMID [PMID 17463246]
Trait Type 2 diabetes
Title Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Risk Allele C
P-val 1E-9
Odds Ratio 1.17 [1.11-1.23]



[PMID 20523342OA-icon.png] IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population

GWAS snp
PMID [PMID 20581827OA-icon.png]
Trait Type 2 diabetes
Title Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Risk Allele C
P-val 2E-9
Odds Ratio 1.14 [1.09-1.19]
GWAS snp
PMID [PMID 22233651OA-icon.png]
Trait
Title A genome-wide association study of gestational diabetes mellitus in korean women.
Risk Allele C
P-val 2E-7
Odds Ratio 1.3320 None


[PMID 22569928OA-icon.png] Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus


[PMID 18426861OA-icon.png] Association analysis of type 2 diabetes Loci in type 1 diabetes.


[PMID 18544707OA-icon.png] Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.


[PMID 18633108OA-icon.png] Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.


[PMID 19008344OA-icon.png] Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.


[PMID 19020323OA-icon.png] Genotype score in addition to common risk factors for prediction of type 2 diabetes.


[PMID 19096518OA-icon.png] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.


[PMID 19956539OA-icon.png] How many genetic variants remain to be discovered?


[PMID 20043853OA-icon.png] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.


[PMID 20144327OA-icon.png] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.


[PMID 22015911] Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk.


[PMID 22245690] Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs.


[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.

GWAS snp
PMID [PMID 22581228OA-icon.png]
Trait
Title A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Risk Allele
P-val 6E-7
Odds Ratio None None


GET Evidence
rs1470579
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.442623
summary



GWAS snp
PMID [PMID 23300278OA-icon.png]
Trait Type 2 diabetes
Title Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India.
Risk Allele C
P-val 2E-13
Odds Ratio 1.06 [1.04-1.08]


[PMID 22749234] Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARγ, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs


[PMID 23462794OA-icon.png] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.

GWAS snp
PMID [PMID 23945395]
Trait Type 2 diabetes
Title Genome-wide association study identifies three novel loci for type 2 diabetes.
Risk Allele C
P-val 5E-14
Odds Ratio 1.19 [1.14-1.24]