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rs1495741

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 NAT2 slow metabolizer (predicted)
(A;G) 2 NAT2 intermediate metabolizer (predicted)
(G;G) 2 NAT2 rapid metabolizer (predicted)
ReferenceGRCh38 38.1/141
Chromosome8
Position18415371
is asnp
is mentioned by
dbSNPrs1495741
ebirs1495741
HLIrs1495741
Exacrs1495741
Varsomers1495741
Maprs1495741
PheGenIrs1495741
hapmaprs1495741
1000 genomesrs1495741
hgdprs1495741
ensemblrs1495741
gopubmedrs1495741
geneviewrs1495741
scholarrs1495741
googlers1495741
pharmgkbrs1495741
gwascentralrs1495741
openSNPrs1495741
23andMers1495741
23andMe allrs1495741
SNP Nexus

SNPshotrs1495741
SNPdbers1495741
MSV3drs1495741
GWAS Ctlgrs1495741
GMAF0.3774
Max Magnitude2
With 99% sensitivity and 95% specificity, at least in Caucasian populations, rs1495741 is reported to classify the NAT2 phenotype of an individual; it therefore is a candidate to replace the 7-SNP panel used in genosets such as gs138, gs139, and gs140. The rs1495741(A;A), (A;G) and (G;G) genotypes predicted slow, intermediate, and rapid NAT2 acetylation phenotypes, respectively.[PMID 20739907OA-icon.png]
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 20972438OA-icon.png]
Trait
Title A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Risk Allele
P-val 4E-11
Odds Ratio 1.1500 [1.10-1.20]


[PMID 21750470] Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype


[PMID 22092036OA-icon.png] Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes

GWAS snp
PMID [PMID 20686565OA-icon.png]
Trait
Title Biological, clinical and population relevance of 95 loci for blood lipids.
Risk Allele G
P-val 4E-14
Odds Ratio 2.9700 None


[PMID 22686316] Polymorphic enzymes, urinary bladder cancer risk, and structural change in the local industry


[PMID 22336957] Impact of population diversity on the prediction of 7-SNP NAT2 phenotypes using the tagSNP rs1495741 or paired SNPs.


[PMID 22414877OA-icon.png] Novel tagging SNP rs1495741 and 2-SNPs (rs1041983 and rs1801280) yield a high prediction of the NAT2 genotype in HapMap samples.


[PMID 24524665] Improvements in Algorithms for Phenotype Inference: The NAT2 Example


[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.


[PMID 23407048] The NAT2 tag SNP rs1495741 correlates with the susceptibility of antituberculosis drug-induced hepatotoxicity.

GWAS snp
PMID [PMID 24163127OA-icon.png]
Trait Bladder cancer
Title Genome-wide association study identifies multiple loci associated with bladder cancer risk.
Risk Allele A
P-val 2E-10
Odds Ratio 1.14 [1.09-1.18]
GWAS snp
PMID [PMID 24097068OA-icon.png]
Trait Cholesterol, total
Title Discovery and refinement of loci associated with lipid levels.
Risk Allele G
P-val 3E-8
Odds Ratio .03 [NR] unit increase
GWAS snp
PMID [PMID 24816252OA-icon.png]
Trait Blood metabolite levels
Title An atlas of genetic influences on human blood metabolites.
Risk Allele A
P-val 1E-27
Odds Ratio .06 [0.047-0.067] unit increase


[PMID 25794903] Determination of NAT2 acetylation status in the Greenlandic population