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rs1495965

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 1.2x higher risk for spondylitis
(A;G) 1.2x higher risk for spondylitis
(G;G) normal risk
(T;T) 0
ReferenceGRCh38 38.1/141
Chromosome1
Position67287825
GeneIL23R
is asnp
is mentioned by
dbSNPrs1495965
ebirs1495965
HLIrs1495965
Exacrs1495965
Varsomers1495965
Maprs1495965
PheGenIrs1495965
hapmaprs1495965
1000 genomesrs1495965
hgdprs1495965
ensemblrs1495965
gopubmedrs1495965
geneviewrs1495965
scholarrs1495965
googlers1495965
pharmgkbrs1495965
gwascentralrs1495965
openSNPrs1495965
23andMers1495965
23andMe allrs1495965
SNP Nexus

SNPshotrs1495965
SNPdbers1495965
MSV3drs1495965
GWAS Ctlgrs1495965
GMAF0.4522
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs1495965 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 1.2 (p=6.6x10e-6).[PMID 17952073, PMID 18037607]

23andMe reports that the CC genotype at rs1495965 is associated with 1.56x higher odds of Behçet's disease, and the TT genotype with 0.64x lower odds, than the CT genotype. [PMID 20622879]

[PMID 18713787] rs11209032 and rs1495965 no significant association with systemic sclerosis


[PMID 19034457] Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility


[PMID 19334001] Contribution of IL23R but not ATG16L1 to Crohn's disease susceptibility in Koreans

GWAS snp
PMID [PMID 20622879]
Trait Behcet's disease
Title Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci
Risk Allele G
P-val 2E-11
Odds Ratio 1.35 [1.24-1.47]


[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis

[PMID 17068223OA-icon.png] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.

[PMID 17678723] Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.

[PMID 17786191OA-icon.png] rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.

[PMID 18200510] CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population.

[PMID 18470928OA-icon.png] IL23R haplotypes provide a large population attributable risk for Crohn's disease.

[PMID 19175939OA-icon.png] IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.

[PMID 19306001] No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus.

[PMID 20454450OA-icon.png] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.

[PMID 21304977OA-icon.png] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

[PMID 22378604] Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Behcet's disease.


[PMID 24998354] Determination of IL-23 receptor gene polymorphism in Iranian patients with ankylosing spondylitis