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rs1528133

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 normal risk
(A;C) higher body mass index
(C;C) higher body mass index
(T;T) 0
ReferenceGRCh38 38.1/142
Chromosome11
Position8128206
GeneRIC3
is asnp
is mentioned by
dbSNPrs1528133
ebirs1528133
HLIrs1528133
Exacrs1528133
Varsomers1528133
Maprs1528133
PheGenIrs1528133
hapmaprs1528133
1000 genomesrs1528133
hgdprs1528133
ensemblrs1528133
gopubmedrs1528133
geneviewrs1528133
scholarrs1528133
googlers1528133
pharmgkbrs1528133
gwascentralrs1528133
openSNPrs1528133
23andMers1528133
23andMe allrs1528133
SNP Nexus

SNPshotrs1528133
SNPdbers1528133
MSV3drs1528133
GWAS Ctlgrs1528133
GMAF0.08907
Max Magnitude0
? (A;A) (A;C) (C;C) 28
rs1528133, a SNP in the TUB gene, was found in a study of 492 unrelated type-2 diabetes patients to have a significant effect on body mass index and thus obesity (1.54 kg/m(2), p= 0.006). When two populations were combined, totaling ~1200 patients, the risk allele (rs1528133(C) averaged an increase of 0.54 kg/m2 (CI: –0.19-1.26). Two additional TUB SNPs, rs2272382, and rs2272383, mapping to the 3' end of the gene showed similar associations and were in linkage disequilibrium with rs1528133.[PMID 16443771]

A follow-up study of 1,680 middle-aged Dutch women found that this allele, rs1528133(C), was significantly associated with increased weight (+1.88 kg, p=0.022) and body mass index (+0.56 units, p= 0.05). rs1528133(C) carriers were also associated with an increased glycemic load of 1.85 units compared with non-carriers.[PMID 18183286OA-icon.png]

[PMID 17955208] TUB is a candidate gene for late-onset obesity in women.


[PMID 23153976] Relationship of RIC-3 gene rs1528133 polymorphism with varying degrees of body weight and eating behavior