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rs1532624

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) 0 common in clinvar
Make rs1532624(G;T)
Make rs1532624(T;T)
ReferenceGRCh38 38.1/141
Chromosome16
Position56971567
GeneCETP
is asnp
is mentioned by
dbSNPrs1532624
ebirs1532624
HLIrs1532624
Exacrs1532624
Varsomers1532624
Maprs1532624
PheGenIrs1532624
hapmaprs1532624
1000 genomesrs1532624
hgdprs1532624
ensemblrs1532624
gopubmedrs1532624
geneviewrs1532624
scholarrs1532624
googlers1532624
pharmgkbrs1532624
gwascentralrs1532624
openSNPrs1532624
23andMers1532624
23andMe allrs1532624
SNP Nexus

SNPshotrs1532624
SNPdbers1532624
MSV3drs1532624
GWAS Ctlgrs1532624
GMAF0.3062
Max Magnitude0
? (G;G) (G;T) (T;T) 28
GWAS snp
PMID [PMID 19060911OA-icon.png]
Trait HDL cholesterol
Title Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Risk Allele C
P-val 9E-94
Odds Ratio 0.21 [NR] SD decrease


GWAS snp
PMID [PMID 20066028OA-icon.png]
Trait Cholesterol
Title Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels
Risk Allele
P-val 3E-20
Odds Ratio 9.99 [NR] mg/dl increase between hmz


[PMID 21252145OA-icon.png] Physical Activity Modifies the Effect of LPL, LIPC and CETP Polymorphisms on HDL-C Levels and the Risk of Myocardial Infarction in Caucasian Women

OMIM118470
Desc
Variant
Relatedalso
[PMID 16700901OA-icon.png] Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction.

[PMID 18254975OA-icon.png] Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.

[PMID 19041386OA-icon.png] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

[PMID 19682379OA-icon.png] TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population.

[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

[PMID 20031564OA-icon.png] Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study.

[PMID 20502693OA-icon.png] Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.


GET Evidence
rs1532624
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.335938
summary



GWAS snp
PMID [PMID 23505323OA-icon.png]
Trait HDL cholesterol
Title Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
Risk Allele A
P-val 1E-24
Odds Ratio .23 [0.19-0.27] unit increase


[PMID 24160573] Cholesteryl Ester Transfer Protein rs1532624 Gene Polymorphism is Associated with Reduced Response to Statin Therapy


[PMID 24283500OA-icon.png] CETP gene polymorphisms and risk of coronary atherosclerosis in a Chinese population

GWAS snp
PMID [PMID 19936222]
Trait Lipid metabolism phenotypes
Title Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
Risk Allele
P-val 1E-39
Odds Ratio 3.92 [NR] unit increase


ClinVar
Risk rs1532624(T;T)
Alt rs1532624(T;T)
Reference rs1532624(G;G)
Significance Drug-response
Disease hmg coa reductase inhibitors response - Efficacy
Variation info
Gene CETP
CLNDBN hmg coa reductase inhibitors response - Efficacy
Reversed 1
HGVS NC_000016.9:g.57005479C>A
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211241.1,