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rs1545843

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.4 1.4x increased risk for depression (for those under 55)
(A;G) 0
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome12
Position84170289
is asnp
is mentioned by
dbSNPrs1545843
ebirs1545843
HLIrs1545843
Exacrs1545843
Varsomers1545843
Maprs1545843
PheGenIrs1545843
hapmaprs1545843
1000 genomesrs1545843
hgdprs1545843
ensemblrs1545843
gopubmedrs1545843
geneviewrs1545843
scholarrs1545843
googlers1545843
pharmgkbrs1545843
gwascentralrs1545843
openSNPrs1545843
23andMers1545843
23andMe allrs1545843
SNP Nexus

SNPshotrs1545843
SNPdbers1545843
MSV3drs1545843
GWAS Ctlgrs1545843
GMAF0.4904
Max Magnitude1.4
? (A;A) (A;G) (G;G) 28
rs1545843 is one of two linked SNPs potentially associated (at a distance though) with the SLC6A15 gene; the other is rs1031681.

A GWAS study and meta-analysis ultimately including six independent samples, primarily Caucasion/European but also including an African-American sample, found that the rs1545843(A) allele was associated with higher risk for major depression, but only in individuals less than 55 years old and only when homozygous, with an odds ratio of 1.4 (p = 2 x 10e-8).[PMID 21521612OA-icon.png]


[PMID 22475622] A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression