Have questions? Visit https://www.reddit.com/r/SNPedia

rs1570360

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 3x risk
(A;G) 3x risk
(G;G) normal
ReferenceGRCh38 38.1/141
Chromosome6
Position43770093
GeneVEGFA
is asnp
is mentioned by
dbSNPrs1570360
ebirs1570360
HLIrs1570360
Exacrs1570360
Varsomers1570360
Maprs1570360
PheGenIrs1570360
hapmaprs1570360
1000 genomesrs1570360
hgdprs1570360
ensemblrs1570360
gopubmedrs1570360
geneviewrs1570360
scholarrs1570360
googlers1570360
pharmgkbrs1570360
gwascentralrs1570360
openSNPrs1570360
23andMers1570360
23andMe allrs1570360
SNP Nexus

SNPshotrs1570360
SNPdbers1570360
MSV3drs1570360
GWAS Ctlgrs1570360
GMAF0.2241
Max Magnitude
This position is referred to as the -1154 position in many VEGF-associated publications. The normal (or wild type) form of this SNP is a (G). The (A) form reduces the activity of this gene, resulting in less VEGF protein.

Individuals with one or more rs1570360(A) alleles are reported to be at about a 3 fold higher risk of developing Sudden Infant Death Syndrome [PMID 16916659].


[PMID 19429179] Association between promoter polymorphisms of vascular endothelial growth factor gene and sporadic Alzheimer's disease among Northern Chinese Han

[PMID 19308252OA-icon.png] Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation

[PMID 19594543] Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer


[PMID 20082870] A Single Nucleotide Polymorphism in the Vascular Endothelial Growth Factor Gene Is Associated with Recurrence of Hepatocellular Carcinoma after Transplantation


[PMID 19233472] Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection


[PMID 20132989] Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population


[PMID 20678803] Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration

[PMID 20950367] Association of Vascular Endothelial Growth Factor Gene Polymorphisms with Recurrent Spontaneous Abortion in Chinese Han Women

OMIM192240
Desc
Variant
Relatedalso


[PMID 22015057] Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study


[PMID 22167330] Polymorphism of vascular endothelial growth factor -1154G>A (rs1570360) with cancer risk: a meta-analysis of 16 case-control studies


[PMID 22818823] Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients

[PMID 16142870] A functional variant of vascular endothelial growth factor is associated with severe ischemic complications in giant cell arteritis.

[PMID 16216669] Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis.

[PMID 16395752] Association between functional haplotypes of vascular endothelial growth factor and renal complications in Henoch-Schonlein purpura.

[PMID 16613616OA-icon.png] Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.

[PMID 16685110] Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.

[PMID 16801663] Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS.

[PMID 17204151OA-icon.png] VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis.

[PMID 17319747OA-icon.png] Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk.

[PMID 17625508] VEGF C-634G polymorphism is associated with protection from isolated ventricular septal defect: case-control and TDT studies.

[PMID 18441306] VEGF polymorphisms are associated with severity of diabetic retinopathy.

[PMID 19551141OA-icon.png] Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.

[PMID 19587357OA-icon.png] A systematic meta-analysis of genetic association studies for diabetic retinopathy.

[PMID 19603096OA-icon.png] An analysis of growth, differentiation and apoptosis genes with risk of renal cancer.

[PMID 19755511OA-icon.png] The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.

[PMID 19842071] No association of VEGF polymorphims with Alzheimer's disease.

[PMID 20140301] VEGFA polymorphisms and cardiovascular anomalies in 22q11 microdeletion syndrome: a case-control and family-based study.

[PMID 20389299OA-icon.png] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

[PMID 20444917] Association of vascular endothelial growth factor polymorphisms with nonproliferative and proliferative diabetic retinopathy.

[PMID 20706635OA-icon.png] Human genetics of diabetic retinopathy: current perspectives.

[PMID 21080079] Gene polymorphism of vascular endothelial growth factor -1154 G>A is associated with hypertensive nephropathy in a Hispanic population.

[PMID 21257617] Association of polymorphisms/haplotypes of the genes encoding vascular endothelial growth factor and its KDR receptor with recurrent pregnancy loss.

[PMID 21347390OA-icon.png] Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.

[PMID 21388351] Vascular endothelial growth factor A and cardiovascular disease in rheumatoid arthritis patients.

[PMID 21982816] Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.


[PMID 23211130] Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage


[PMID 23404364] Polymorphisms in the VEGFA promoter are associated with susceptibility to hepatocellular carcinoma by altering promoter activity


[PMID 24177231] The RTK/ERK Pathway is associated with Prostate Cancer Risk on the SNP level: a pooled analysis of 41 sets of data from case-control studies


[PMID 24321896] Effect of Genetic Polymorphisms of Vascular Endothelial Growth Factor on Left Ventricular Hypertrophy in Patients With Systemic Hypertension


[PMID 22729570] AKT3, ANGPTL4, eNOS3, and VEGFA associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.


[PMID 22925497] The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.


[PMID 23007311] VEGF genetic polymorphisms affect the responsiveness to sildenafil in clinical and postoperative erectile dysfunction.


[PMID 23545315] Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility.


[PMID 23553563] VEGFA SNPs and transcriptional factor binding sites associated with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.


[PMID 24868559OA-icon.png] The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies


[PMID 24935327] Haplotype Analysis on Chromosome 6p of Tumor Necrosis Factor Alpha, Vascular Endothelial Growth Factor A, and Interleukin-17F Alleles Associated With Corneal Transplant Rejection


[PMID 24940484OA-icon.png] Association between vascular endothelial growth factor gene polymorphisms and bladder cancer risk


[PMID 25148899] Investigating the association of vascular endothelial growth factor polymorphisms with breast cancer: a Moroccan case-control study


[PMID 25894981] Genetic Variations of VEGF Gene Were Associated with Tetralogy of Fallot Risk in a Chinese Han Population


[PMID 26002049] Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril


[PMID 26264619] Vascular endothelial growth factor polymorphisms and a synchronized examination of plasma and tissue expression in epithelial ovarian cancers


[PMID 26305668] The Relationship between Vascular Endothelial Growth Factor 1154G/A Polymorphism and Recurrent Implantation Failure


[PMID 26486233] Vascular endothelial growth factor (VEGF)-634G/C polymorphism was associated with severe pre-eclampsia and lower serum VEGF level