Have questions? Visit https://www.reddit.com/r/SNPedia

rs1573496

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;G) 0.68x decreased risk of oral/throat cancers
(G;G) 0.68x decreased risk of oral/throat cancers
ReferenceGRCh38 38.1/141
Chromosome4
Position99428512
GeneADH7
is asnp
is mentioned by
dbSNPrs1573496
ebirs1573496
HLIrs1573496
Exacrs1573496
Varsomers1573496
Maprs1573496
PheGenIrs1573496
hapmaprs1573496
1000 genomesrs1573496
hgdprs1573496
ensemblrs1573496
gopubmedrs1573496
geneviewrs1573496
scholarrs1573496
googlers1573496
pharmgkbrs1573496
gwascentralrs1573496
openSNPrs1573496
23andMers1573496
23andMe allrs1573496
SNP Nexus

SNPshotrs1573496
SNPdbers1573496
MSV3drs1573496
GWAS Ctlgrs1573496
GMAF0.05785
Max Magnitude0
? (C;C) (C;G) (G;G) 28
rs1573496 is a SNP in the ADH7 alcohol dehydrogenase 7 gene.

A study of over 3,800 cases of "upper aerodigestive" cancers (mouth/throat, voice box, and esophageal cancers) concluded that the rs1573496(G) allele has a protective effect. Carriers of this allele had a 0.68x (decreased; p=10-9) risk of having one of these cancer types.[PMID 18500343]


[PMID 19861527] Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population


[PMID 20336794OA-icon.png] A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck

OMIM103720
Desc
Variant
Relatedalso
[PMID 21437268OA-icon.png] A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium. The data in this paper, makes it seem that (G;G) was much more common. This is inconsistent with the HapMap frequencies, suggesting the sequence may have been flipped.

[PMID 16685648OA-icon.png] Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.

[PMID 17185388OA-icon.png] Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.

[PMID 17273965OA-icon.png] Evidence of positive selection on a class I ADH locus.

[PMID 18331377OA-icon.png] Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.

[PMID 19193628OA-icon.png] ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.

[PMID 19298322OA-icon.png] Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans.

[PMID 19687126OA-icon.png] A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.

[PMID 20700531OA-icon.png] The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.


GET Evidence
ADH7-G92A
aa_change Gly92Ala
aa_change_short G92A
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0795687
summary



[PMID 23149980] Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

Esophageal Cancer: Preliminary Research

Larynx Cancer

Oral and Throat Cancers