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rs157580

From SNPedia

Orientationplus
Stabilizedplus
Make rs157580(A;A)
Make rs157580(A;G)
Make rs157580(G;G)
ReferenceGRCh38 38.1/141
Chromosome19
Position44892009
GeneTOMM40
is asnp
is mentioned by
dbSNPrs157580
ebirs157580
HLIrs157580
Exacrs157580
Varsomers157580
Maprs157580
PheGenIrs157580
hapmaprs157580
1000 genomesrs157580
hgdprs157580
ensemblrs157580
gopubmedrs157580
geneviewrs157580
scholarrs157580
googlers157580
pharmgkbrs157580
gwascentralrs157580
openSNPrs157580
23andMers157580
23andMe allrs157580
SNP Nexus

SNPshotrs157580
SNPdbers157580
MSV3drs157580
GWAS Ctlgrs157580
GMAF0.371
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 19125160]
Trait Alzheimer's disease
Title Examination of the current top candidate genes for AD in a genome-wide association study
Risk Allele
P-val 1E-40
Odds Ratio NR NR
GWAS snp
PMID [PMID 19060911OA-icon.png]
Trait HDL cholesterol
Title Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Risk Allele G
P-val 4E-7
Odds Ratio 0.06 [NR] SD increase
GWAS snp
PMID [PMID 19060910OA-icon.png]
Trait LDL cholesterol
Title Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Risk Allele G
P-val 5E-8
Odds Ratio 0.11 [0.07-0.15] mmol/l decrease


The G allele of this SNP in the TOMM40 gene may be associated with late-onset Alzheimer's disease.




GWAS snp
PMID [PMID 21123754OA-icon.png]
Trait
Title Genome-wide association study of CSF biomarkers A{beta}1-42, t-tau, and p-tau181p in the ADNI cohort.
Risk Allele
P-val 0.000001
Odds Ratio None None
GWAS snp
PMID [PMID 21627779OA-icon.png]
Trait
Title The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.
Risk Allele
P-val 8E-89
Odds Ratio 1.6900 [NR]

[PMID 17658295] Association of ApoE genetic variants with obstructive sleep apnea in children.

[PMID 18439548OA-icon.png] Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.

[PMID 18823527OA-icon.png] A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.

[PMID 19668339OA-icon.png] Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.

[PMID 19734902OA-icon.png] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

[PMID 20061627OA-icon.png] Genome-wide scan of copy number variation in late-onset Alzheimer's disease.

[PMID 20502693OA-icon.png] Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

[PMID 21390209OA-icon.png] Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.


GET Evidence
rs157580
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.722222
summary



[PMID 23435269OA-icon.png] Chronic Family Stress Moderates the Association between a TOMM40 Variant and Triglyceride Levels in Two Independent Caucasian Samples


[PMID 23288655] Association of TOMM40 polymorphisms with late-onset Alzheimer's disease in a Northern Han Chinese population


[PMID 22430674OA-icon.png] Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.


[PMID 23193196OA-icon.png] Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.


[PMID 23546992] TOMM40 polymorphisms in Italian Alzheimer's disease and frontotemporal dementia patients.


[PMID 25711031] [TOMM40 gene polymorphism association with lipid profile]


[PMID 26252223OA-icon.png] Genetic Variants Associated with Lipid Profiles in Chinese Patients with Type 2 Diabetes


[PMID 26543236] Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population