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rs1613662

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
Make rs1613662(A;G)
Make rs1613662(G;G)
ReferenceGRCh37 37.1/132
Chromosome19
Position55536595
GeneGP6
is asnp
is mentioned by
dbSNPrs1613662
ebirs1613662
HLIrs1613662
Exacrs1613662
Varsomers1613662
Maprs1613662
PheGenIrs1613662
hapmaprs1613662
1000 genomesrs1613662
hgdprs1613662
ensemblrs1613662
gopubmedrs1613662
geneviewrs1613662
scholarrs1613662
googlers1613662
pharmgkbrs1613662
gwascentralrs1613662
openSNPrs1613662
23andMers1613662
23andMe allrs1613662
SNP Nexus

SNPshotrs1613662
SNPdbers1613662
MSV3drs1613662
GWAS Ctlgrs1613662
GMAF0.1309
Max Magnitude0
? (A;A) (A;G) (G;G) 28
Gene variants associated with deep vein thrombosis.[PMID 18349091]

Updated analysis of gene variants associated with deep vein thrombosis.[PMID 20124536]

per risk allele odds ratio

  • rs13146272 in CYP4V2 (risk allele frequency, 0.64) OR 1.24 (95% CI, 1.11-1.37) for rs13146272
  • rs2227589 in SERPINC1 (risk allele frequency, 0.10) OR 1.29 (95% CI, 1.10-1.49) for rs2227589
  • rs1613662 in GP6 (risk allele frequency, 0.84) OR 1.15 (95% CI, 1.01-1.30) for rs1613662

A study of 453 VTE cases and 1,327 controls was able to replicate the "mild effects" of this SNP on risk for VTE, however they felt that stronger associations were found between increased VTE risk and either the Factor V Leiden mutation (rs6025)or having blood types O or A2.[PMID 19278955]


[PMID 19786296] Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction


[PMID 22133274OA-icon.png] Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection

[PMID 20031567OA-icon.png] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.

[PMID 21232005OA-icon.png] New gene variants associated with venous thrombosis: a replication study in White and Black Americans.

[PMID 21854539] Genetic determinants of platelet reactivity during acetylsalicylic acid therapy in diabetic patients: evaluation of 27 polymorphisms within candidate genes.


GET Evidence
GP6-P219S
aa_change Pro219Ser
aa_change_short P219S
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.824489
summary



[PMID 23150947] Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study


[PMID 23168074] The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke


[PMID 23739280] Association study of the platelet collagen receptor glycoprotein VI gene with rheumatoid arthritis


[PMID 22821001] Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism.


[PMID 22901851] Platelet aggregation abnormalities in patients with fetal losses: the GP6 gene polymorphism.


[PMID 25091233] Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia


[PMID 25901734] Effect of platelet receptor gene polymorphisms on outcomes in ST-elevation myocardial infarction patients after percutaneous coronary intervention