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rs1625579

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0
Make rs1625579(A;A)
Make rs1625579(A;C)
ReferenceGRCh38 38.1/141
Chromosome1
Position98037378
GeneMIR137HG
is asnp
is mentioned by
dbSNPrs1625579
ebirs1625579
HLIrs1625579
Exacrs1625579
Varsomers1625579
Maprs1625579
PheGenIrs1625579
hapmaprs1625579
1000 genomesrs1625579
hgdprs1625579
ensemblrs1625579
gopubmedrs1625579
geneviewrs1625579
scholarrs1625579
googlers1625579
pharmgkbrs1625579
gwascentralrs1625579
openSNPrs1625579
23andMers1625579
23andMe allrs1625579
SNP Nexus

SNPshotrs1625579
SNPdbers1625579
MSV3drs1625579
GWAS Ctlgrs1625579
GMAF0.1882
Max Magnitude0
? (A;A) (A;C) (C;C) 28
[PMID 21926974OA-icon.png] schizophrenia, p = 1.6 x 10^-11, top hit in a rather large combined sample of (stage 1) 21,856 Europeans and (stage 2, replication) 29,839 independent individuals, see also this post on the Schizophrenia Research Forum

Per the above reference, this SNP is located within an intron of miR-137 / MIR137 (on Wikipedia). Four other additional loci containing predictive targets of this microRNA also passed the threshold for genome-wide significance.. potentially suggesting some involvement of miR-137 mediated activity in the disease.

[PMID 22733126] Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia.


[PMID 22982201] Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137


[PMID 22910404] Genetic association study of the P300 endophenotype in schizophrenia

GWAS snp
PMID [PMID 23453885OA-icon.png]
Trait Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)
Title Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Risk Allele
P-val 2E-11
Odds Ratio NR NR


[PMID 23786914OA-icon.png] Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex


[PMID 22850735OA-icon.png] Impact of a microRNA MIR137 susceptibility variant on brain function in people at high genetic risk of schizophrenia or bipolar disorder.


[PMID 22883350OA-icon.png] Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137.


[PMID 23459466] The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia.


[PMID 24820543] Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants


[PMID 25084801] Association of microRNA137 Gene Polymorphisms with Age at Onset and Positive Symptoms of Schizophrenia in a Han Chinese Population


[PMID 25241074] Lack of association between microRNA-137 SNP rs1625579 and schizophrenia in a replication study of Han Chinese


[PMID 25250332OA-icon.png] Association of a miRNA-137 Polymorphism with Schizophrenia in a Southern Chinese Han Population


[PMID 26429811] A GWAS SNP for Schizophrenia Is Linked to the Internal MIR137 Promoter and Supports Differential Allele-Specific Expression


[PMID 27095331] The SNP rs1625579 in miR-137 gene and risk of schizophrenia in Chinese population: A meta-analysis.


[PMID 27481827] Testing the Validity of Taxonic Schizotypy Using Genetic and Environmental Risk Variables.