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rs16260

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.6x increased risk of prostate cancer
(A;C) 1.5-1.7x increased risk of prostate cancer
(C;C) 0 normal
ReferenceGRCh38 38.1/141
Chromosome16
Position68737131
GeneCDH1
is asnp
is mentioned by
dbSNPrs16260
ebirs16260
HLIrs16260
Exacrs16260
Varsomers16260
Maprs16260
PheGenIrs16260
hapmaprs16260
1000 genomesrs16260
hgdprs16260
ensemblrs16260
gopubmedrs16260
geneviewrs16260
scholarrs16260
googlers16260
pharmgkbrs16260
gwascentralrs16260
openSNPrs16260
23andMers16260
23andMe allrs16260
SNP Nexus

SNPshotrs16260
SNPdbers16260
MSV3drs16260
GWAS Ctlgrs16260
GMAF0.2323
Max Magnitude0
? (A;A) (A;C) (C;C) 28

[PMID 14961571, PMID 16189707] rs16260 (A) SNP located in the promoter region of the E-cadherin CDH1 gene is associated with increased risk of hereditary prostate cancer.

The effect appears to be additive, in that compared to the rs16260(C;C) homozygotes, the rs16260(A;C) heterozygotes are at about a 1.5 - 1.7 fold increased risk, and the rs16260(A;A) homozygotes are at about a 2.6 fold increased risk.


[PMID 19569232] The CDH1-160C>A polymorphism is a risk factor for colorectal cancer


[PMID 20044998] Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis

[PMID 20880515] Association of CDH1 promoter polymorphism and the risk of non-syndromic orofacial clefts in a Chinese Han population

OMIM192090
Desc
Variant0018
Relatedalso


[PMID 22535324] CDH1 gene polymorphisms, plasma CDH1 levels and risk of gastric cancer in a Chinese population


[PMID 22792244OA-icon.png] Contribution of the -160C/A Polymorphism in the E-cadherin Promoter to Cancer Risk: A Meta-Analysis of 47 Case-Control Studies


[PMID 14724163OA-icon.png] Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.


[PMID 19011631OA-icon.png] Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.


[PMID 19034965OA-icon.png] Genetic determination of irritable bowel syndrome.


[PMID 19551141OA-icon.png] Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.


[PMID 19567509OA-icon.png] Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.


[PMID 19671196OA-icon.png] Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients.


[PMID 20632448OA-icon.png] Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk.


[PMID 22330421] E-cadherin polymorphisms and susceptibility to arsenic-related skin lesions in West Bengal, India.


[PMID 23231047] Association Between CDH1 and MSX1 Gene Polymorphisms and the Risk of Nonsyndromic Cleft Lip and/or Cleft Palate in a Southeast Iranian Population


[PMID 24023817OA-icon.png] The -160C>A Polymorphism in e-Cadherin Is Associated with the Risk of Nephrolithiasis


[PMID 10706097] A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities.


[PMID 24838934OA-icon.png] Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate


[PMID 25150394] Genetic variation of the E-cadherin gene is associated with primary infertility in patients with ovarian endometriosis


ClinVar
Risk rs16260(A;A)
Alt rs16260(A;A)
Reference rs16260(C;C)
Significance Other
Disease Prostate cancer
Variation info
Gene CDH1
CLNDBN Prostate cancer, susceptibility to
Reversed 0
HGVS NC_000016.9:g.68771034C>A
CLNSRC OMIM Allelic Variant
CLNACC RCV000013034.3,



[PMID 27852262] E-cadherin genetic variants predict survival outcome in breast cancer patients.