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From SNPedia

Geno Mag Summary
(A;A) 0
(A;G) 1
(G;G) 1.5 May indicate increased susceptibility to schizophrenia
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs165599
23andMe allrs165599
SNP Nexus

GWAS Ctlgrs165599
Max Magnitude1.5
anxiety-related personality traits, ADHD, schizophrenia

part of a three marker haplotype rs737865-rs4680-rs165599

epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes

popular in pubmed

[PMID 17547583] is associated with bipolar disorder and influences prefrontal aspects of verbal memory in bipolar patients and healthy controls.

[PMID 19369177] Association of the 3' Region of COMT with Schizophrenia in Taiwan

[PMID 19077118] Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia

[PMID 19095219] Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder

[PMID 19605537OA-icon.png] Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children

[PMID 20586531] The catechol-O-methyl-transferase gene in tardive dyskinesia

[PMID 21595525] Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder

[PMID 21934638] A COMT gene haplotype associated with methamphetamine abuse

[PMID 21940152] The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study

[PMID 15570503] No evidence for gender-specific sharing of COMT alleles in schizophrenia

[PMID 12802784OA-icon.png] A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.

[PMID 15098000] COMT haplotypes suggest P2 promoter region relevance for schizophrenia.

[PMID 15124004] Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families.

[PMID 15457404OA-icon.png] Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.

[PMID 15505638] Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.

[PMID 15635644] A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).

[PMID 15931594OA-icon.png] An entropy-based statistic for genomewide association studies.

[PMID 15956988] COMT polymorphisms and anxiety-related personality traits.

[PMID 15962707] The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia.

[PMID 16027741] Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.

[PMID 16232322OA-icon.png] COMT genetic variation confers risk for psychotic and affective disorders: a case control study.

[PMID 16380905OA-icon.png] Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.

[PMID 16483362OA-icon.png] The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.

[PMID 16525418] Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder.

[PMID 16786032] Impact of complex genetic variation in COMT on human brain function.

[PMID 16816420OA-icon.png] Nonlinear tests for genomewide association studies.

[PMID 17006672] Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.

[PMID 17363961] Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.

[PMID 17427186] Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.

[PMID 17466074OA-icon.png] Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.

[PMID 17482701] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.

[PMID 17630406OA-icon.png] Dopamine genes and schizophrenia: case closed or evidence pending?

[PMID 17707347OA-icon.png] Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls.

[PMID 17949513] Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS.

[PMID 17961261OA-icon.png] Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.

[PMID 18021915OA-icon.png] Genetics and smoking cessation improving outcomes in smokers at risk.

[PMID 18081002] Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials.

[PMID 18384078] Association study of candidate variants of COMT with neuroticism, anxiety and depression.

[PMID 18436194OA-icon.png] Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.

[PMID 18466879OA-icon.png] Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample.

[PMID 18574484OA-icon.png] The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.

[PMID 18704099OA-icon.png] Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.

[PMID 18715757OA-icon.png] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.

[PMID 19071221OA-icon.png] Impact of interacting functional variants in COMT on regional gray matter volume in human brain.

[PMID 19329282] Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.

[PMID 19365560OA-icon.png] Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.

[PMID 19721400] Association between COMT gene and Chinese male schizophrenic patients with violent behavior.

[PMID 20080926] The influence of 5-HTT and COMT genotypes on verbal fluency in ecstasy users.

[PMID 20531207] The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.

[PMID 20627703] The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.

[PMID 20667552] Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 21462137] [An association study of COMT gene polymorphisms with schizophrenia].

[PMID 21609749] Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability.

[PMID 21788083] Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.

GET Evidence
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.586207

[PMID 24320736] Role of single nucleotide polymorphisms in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma in Han Chinese: A case-control study

[PMID 22713126] COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder.

[PMID 23178897OA-icon.png] The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.

[PMID 23332465] Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets

[PMID 23598060] Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia

[PMID 26849490] Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.

[PMID 27228319] A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene.