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rs165599

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0
(A;G) 1
(G;G) 1.5 May indicate increased susceptibility to schizophrenia
ReferenceGRCh38 38.1/141
Chromosome22
Position19969258
GeneARVCF, COMT
is asnp
is mentioned by
dbSNPrs165599
ebirs165599
HLIrs165599
Exacrs165599
Varsomers165599
Maprs165599
PheGenIrs165599
hapmaprs165599
1000 genomesrs165599
hgdprs165599
ensemblrs165599
gopubmedrs165599
geneviewrs165599
scholarrs165599
googlers165599
pharmgkbrs165599
gwascentralrs165599
openSNPrs165599
23andMers165599
23andMe allrs165599
SNP Nexus

SNPshotrs165599
SNPdbers165599
MSV3drs165599
GWAS Ctlgrs165599
GMAF0.4656
Max Magnitude1.5
anxiety-related personality traits, ADHD, schizophrenia

part of a three marker haplotype rs737865-rs4680-rs165599

epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes

popular in pubmed

[PMID 17547583] is associated with bipolar disorder and influences prefrontal aspects of verbal memory in bipolar patients and healthy controls.


[PMID 19369177] Association of the 3' Region of COMT with Schizophrenia in Taiwan


[PMID 19077118] Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia

[PMID 19095219] Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder

OMIM104300
DescALZHEIMER DISEASE; AD
Variant
Relatedalso
OMIM116790
DescCATECHOL-O-METHYLTRANSFERASE; COMT
Variant
Relatedalso
[PMID 19605537OA-icon.png] Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children



[PMID 20586531] The catechol-O-methyl-transferase gene in tardive dyskinesia



[PMID 21595525] Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder


[PMID 21934638] A COMT gene haplotype associated with methamphetamine abuse


[PMID 21940152] The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study


[PMID 15570503] No evidence for gender-specific sharing of COMT alleles in schizophrenia


[PMID 12802784OA-icon.png] A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.


[PMID 15098000] COMT haplotypes suggest P2 promoter region relevance for schizophrenia.


[PMID 15124004] Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families.


[PMID 15457404OA-icon.png] Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.


[PMID 15505638] Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.


[PMID 15635644] A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).


[PMID 15931594OA-icon.png] An entropy-based statistic for genomewide association studies.


[PMID 15956988] COMT polymorphisms and anxiety-related personality traits.


[PMID 15962707] The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia.


[PMID 16027741] Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.


[PMID 16232322OA-icon.png] COMT genetic variation confers risk for psychotic and affective disorders: a case control study.


[PMID 16380905OA-icon.png] Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.


[PMID 16483362OA-icon.png] The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.


[PMID 16525418] Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder.


[PMID 16786032] Impact of complex genetic variation in COMT on human brain function.


[PMID 16816420OA-icon.png] Nonlinear tests for genomewide association studies.


[PMID 17006672] Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.


[PMID 17363961] Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.


[PMID 17427186] Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.


[PMID 17466074OA-icon.png] Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.


[PMID 17482701] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.


[PMID 17630406OA-icon.png] Dopamine genes and schizophrenia: case closed or evidence pending?


[PMID 17707347OA-icon.png] Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls.


[PMID 17949513] Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS.


[PMID 17961261OA-icon.png] Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.


[PMID 18021915OA-icon.png] Genetics and smoking cessation improving outcomes in smokers at risk.


[PMID 18081002] Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials.


[PMID 18384078] Association study of candidate variants of COMT with neuroticism, anxiety and depression.


[PMID 18436194OA-icon.png] Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.


[PMID 18466879OA-icon.png] Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample.


[PMID 18574484OA-icon.png] The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.


[PMID 18704099OA-icon.png] Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.


[PMID 18715757OA-icon.png] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.


[PMID 19071221OA-icon.png] Impact of interacting functional variants in COMT on regional gray matter volume in human brain.


[PMID 19329282] Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.


[PMID 19365560OA-icon.png] Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.


[PMID 19721400] Association between COMT gene and Chinese male schizophrenic patients with violent behavior.


[PMID 20080926] The influence of 5-HTT and COMT genotypes on verbal fluency in ecstasy users.


[PMID 20531207] The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.


[PMID 20627703] The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.


[PMID 20667552] Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 21462137] [An association study of COMT gene polymorphisms with schizophrenia].


[PMID 21609749] Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability.


[PMID 21788083] Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.


GET Evidence
rs165599
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.586207
summary



[PMID 24320736] Role of single nucleotide polymorphisms in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma in Han Chinese: A case-control study


[PMID 22713126] COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder.


[PMID 23178897OA-icon.png] The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.


[PMID 23332465] Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets


[PMID 23598060] Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia


[PMID 26849490] Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.


[PMID 27228319] A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene.