rs16754
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | common in clinvar |
| Make rs16754(A;G) |
| Make rs16754(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 32396399 |
| Gene | WT1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs16754 |
| dbSNP (classic) | rs16754 |
| ClinGen | rs16754 |
| ebi | rs16754 |
| HLI | rs16754 |
| Exac | rs16754 |
| Gnomad | rs16754 |
| Varsome | rs16754 |
| LitVar | rs16754 |
| Map | rs16754 |
| PheGenI | rs16754 |
| Biobank | rs16754 |
| 1000 genomes | rs16754 |
| hgdp | rs16754 |
| ensembl | rs16754 |
| geneview | rs16754 |
| scholar | rs16754 |
| rs16754 | |
| pharmgkb | rs16754 |
| gwascentral | rs16754 |
| openSNP | rs16754 |
| 23andMe | rs16754 |
| SNPshot | rs16754 |
| SNPdbe | rs16754 |
| MSV3d | rs16754 |
| GWAS Ctlg | rs16754 |
| GMAF | 0.3223 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 20038731] Single Nucleotide Polymorphism in the Mutational Hotspot of WT1 Predicts a Favorable Outcome in Patients With Cytogenetically Normal Acute Myeloid Leukemia
[PMID 20368538] Impact of IDH1 R132 Mutations and an IDH1 Single Nucleotide Polymorphism in Cytogenetically Normal Acute Myeloid Leukemia: SNP rs11554137 Is an Adverse Prognostic Factor
[PMID 21189390
] WT1 Synonymous SNP rs16754 Correlates With Higher mRNA Expression and Predicts Significantly Improved Outcome in Favorable-Risk Pediatric Acute Myeloid Leukemia: A Report From the Children's Oncology Group
[PMID 21372155] Integrative prognostic risk score in acute myeloid leukemia with normal karyotype
[PMID 21659357] Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
[PMID 22015946] Single nucleotide polymorphism of Wilms' tumor 1 gene rs16754 in Korean patients with cytogenetically normal acute myeloid leukemia
[PMID 22506617] WT1 Mutations and Single Nucleotide Polymorphism rs16754 Analysis of Patients with Pediatric Acute Myeloid Leukemia in a Chinese Population
[PMID 22568493] ID1 expression associates with other molecular markers and is not an independent prognostic factor in cytogenetically normal acute myeloid leukaemia
[PMID 15687485] Variants in the Wilms' tumor gene are associated with focal segmental glomerulosclerosis in the African American population.
[PMID 17267408] Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells.
[PMID 19914700] Single-nucleotide polymorphism in WT1 gene in a hyperplastic intralobar nephrogenic rest with botryoid protrusion.
[PMID 20644087] No prognostic impact of the WT1 gene single nucleotide polymorphism rs16754 in pediatric acute myeloid leukemia.
[PMID 21760594] Wilms' tumor 1 single-nucleotide polymorphism rs16754 does not predict clinical outcome in adult acute myeloid leukemia.
[PMID 21798259] WT1 mutations and polymorphisms in Southeast Asian acute myeloid leukemia.
[PMID 23484026] Single Nucleotide Polymorphisms in the Wilms' Tumour Gene 1 in Clear Cell Renal Cell Carcinoma
[PMID 23956224] The prognostic effect of high diagnostic WT1 gene expression in pediatric AML depends on WT1 SNP rs16754 status: Report from the Children's Oncology Group
[PMID 22895555] Analysis of mutational status, SNP rs16754, and expression levels of Wilms tumor 1 (WT1) gene in acute promyelocytic leukemia.
[PMID 23070125] Analysis of SNP rs16754 of WT1 gene in a series of de novo acute myeloid leukemia patients.
[PMID 23117548] WT1, WTX and CTNNB1 mutation analysis in 43 patients with sporadic Wilms' tumor.
[PMID 26046002] Association between WT1 polymorphisms and susceptibility to breast cancer: results from a case-control study in a southwestern Chinese population
[PMID 26224397] Wilms tumor gene single nucleotide polymorphism rs16754 predicts a favorable outcome in children with acute lymphoblastic leukemia
[PMID 26499507] The Wilms Tumor-1 (WT1) rs2234593 variant is a prognostic factor in normal karyotype acute myeloid leukemia
| ClinVar | |
|---|---|
| Risk | rs16754(G;G) |
| Alt | rs16754(G;G) |
| Reference | Rs16754(A;A) |
| Significance | Non-pathogenic |
| Disease | not specified Meacham syndrome Diffuse mesangial sclerosis Wilms tumor Wilms Tumor |
| Variation | info |
| Gene | WT1 |
| CLNDBN | not specified Meacham syndrome Diffuse mesangial sclerosis Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome Wilms Tumor |
| Reversed | 1 |
| HGVS | NC_000011.9:g.32417945T>C |
| CLNSRC | |
| CLNACC | RCV000179975.3, RCV000274499.1, RCV000282487.1, RCV000331783.1, RCV000374772.1, |
[PMID 27801325] [Association of WT1 rs16754 polymorphism with clinical features and prognosis in patients with acute myeloid leukemia].
[PMID 32629644] Association between the Wilms tumor-1 rs16754 polymorphism and acute myeloid leukemia: A MOOSE-compliant meta-analysis.
