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rs16888589

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) 1.4 1.4x higher risk for colorectal cancer
(G;G) 2 1.9x higher risk for colorectal cancer
ReferenceGRCh38 38.1/141
Chromosome8
Position116623363
is asnp
is mentioned by
dbSNPrs16888589
ebirs16888589
HLIrs16888589
Exacrs16888589
Varsomers16888589
Maprs16888589
PheGenIrs16888589
hapmaprs16888589
1000 genomesrs16888589
hgdprs16888589
ensemblrs16888589
gopubmedrs16888589
geneviewrs16888589
scholarrs16888589
googlers16888589
pharmgkbrs16888589
gwascentralrs16888589
openSNPrs16888589
23andMers16888589
23andMe allrs16888589
SNP Nexus

SNPshotrs16888589
SNPdbers16888589
MSV3drs16888589
GWAS Ctlgrs16888589
GMAF0.07254
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs16888589 is a SNP on ch 8q23 near the EIFH3 gene, and it appears to be able to influence the amount of EIFH3 protein made.

rs16888589 may have a causative role in increasing the risk for colorectal cancer; specifically, the minor (i.e. less frequent) rs16888589(G) allele is associated with more EIFH3 protein, in turn associated with more cancerous cell growth and invasiveness. In a statistical sense, the rs16888589(G) allele is associated with a 1.4 - 2 fold increase in risk. The authors of this study also conclude that several other nearby SNPs (rs16892766 and rs11986063) that have been statistically linked to higher colorectal cancer risk are part of a tightly linked haplotype with rs16888589, i.e. they are often inherited together, but these other SNPs are not likely to be causative since on their own in in vitro experiments they do not influence EIFH3 protein amounts.10.1371/journal.pgen.1001126[PMID 21314996OA-icon.png] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.