Rs1695

From SNPedia

This SNP, in the GSTP1 gene influences asthma risk; the (A) allele encodes the Ile, while the (G) allele encodes the Val. This SNP is also known as GSTP1Val105, or GSTP1 Ile105Val.

This research paper shows that 13- to 21-year-olds exposed to tobacco smoke at home, with this mutation had more severe asthma than those without the mutation. rs1695 is also mentioned in this bbc article

Several papers published findings associating GSTP1 Ile105Val genotypes with bronchial, childhood, or atopic asthma. [PMID 15612961]

Note that some studies, however, have not observed any association between this SNP and asthma in certain populations [PMID 16176403], or even more paradoxically, have observed that rs1695(G;G) homozygotes appear to be somewhat protected (OR 0.29) from developing asthma compared to individuals with rs1695(A;G) or (A;A) genotypes. [PMID 14748821]

A cohort of 1,610 children in the US were studied to determine that the risk for new-onset asthma was highest in rs1695(A;A) homozygotes who participated in 3 or more sports in high-ozone communities. These children were at 6x higher risk (CI: 2.2-7.4). [PMID 18988661]

A study of 3,000 Chinese women with breast cancer concluded that rs1695(G;G) genotype was significantly associated with greater breast cancer risk, particularly in premenopausal women (odds ratio 1.69, CI: 1.17-2.43). The odds increased further if such women reported eating little cruciferous vegetables (then the odds ratio was 2.08, CI: 1.20-3.59).[PMID 18326615]

A relatively small study of 58 patients with different types of cancer receiving docetaxel concluded that rs1695(A;A) homozygotes (i.e. Ile105/Ile105 homozygotes) had a higher risk of developing docetaxel-induced peripheral neuropathy (DIPN), particularly grade 2 or higher. The odds ratio reported was 6.1 (CI: 1.17-31.9, p=0.03).[PMID 19223573]

[PMID 19383894] Genetic Polymorphisms in the Catechol Estrogen Metabolism Pathway and Breast Cancer Risk

[PMID 19403501] In Utero Smoke Exposure, Glutathione S-Transferase P1 Haplotypes, and Respiratory Illness-Related Absence Among Schoolchildren

[PMID 19921428] Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers