|| common in complete genomics
|?|| (A;A) (A;T) (T;T) ||28|
This polymorphism is present in the GRK5 gene found on chromosome 10 and leads to a nonsynonymous change at amino acid 41 (Gln41Leu). The Leu change is more common in African Americans and less common in Europeans. The GRK5-Leu41 was associated with a decreased mortality in African Americans with heart failure or cardiac ischemia([PMID 18425130]).
[PMID 16385451] A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
[PMID 19842931] GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans.
|| Insufficiently evaluated pharmacogenetic