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rs17098707

From SNPedia

Merged intors2230345
Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
Make rs17098707(A;T)
Make rs17098707(T;T)
ReferenceGRCh38 38.1/142
Chromosome10
Position119326585
GeneGRK5
is asnp
is mentioned by
dbSNPrs17098707
ebirs17098707
HLIrs17098707
Exacrs17098707
Varsomers17098707
Maprs17098707
PheGenIrs17098707
hapmaprs17098707
1000 genomesrs17098707
hgdprs17098707
ensemblrs17098707
gopubmedrs17098707
geneviewrs17098707
scholarrs17098707
googlers17098707
pharmgkbrs17098707
gwascentralrs17098707
openSNPrs17098707
23andMers17098707
23andMe allrs17098707
SNP Nexus

SNPshotrs17098707
SNPdbers17098707
MSV3drs17098707
GWAS Ctlgrs17098707
StatusMerged into rs2230345
GMAF0.0879
Max Magnitude0
? (A;A) (A;T) (T;T) 28

This polymorphism is present in the GRK5 gene found on chromosome 10 and leads to a nonsynonymous change at amino acid 41 (Gln41Leu). The Leu change is more common in African Americans and less common in Europeans. The GRK5-Leu41 was associated with a decreased mortality in African Americans with heart failure or cardiac ischemia([PMID 18425130OA-icon.png]).



[PMID 16385451OA-icon.png] A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.


[PMID 19842931OA-icon.png] GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans.


GET Evidence
GRK5-Q41L
aa_change Gln41Leu
aa_change_short Q41L
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0993679
summary