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rs1711437(G;G)

From SNPedia

slightly reduced creatinine clearance
Is agenotype
ofrs1711437
GeneMMP20
Chromosome11
Position102,594,495
mentionedby
Magnitude2.4
ReputeBad
Geno Mag Summary
(A;A) 2 younger, healthier kidney function
(A;G) 2 younger, healthier kidney function
(G;G) 2.4 slightly reduced creatinine clearance

In the BLSA population, the genotype of rs1711437 explains 2.1% of the variation in creatinine clearance and in the InCHIANTI population, the genotype explains 0.9% of the variation. G is the risk allele. For an individual who carries two copies of the G allele, his or her creatinine clearance is approximately that of someone 4–5 years older who carries no G alleles.

The association between rs1711437 genotype and creatinine clearance has not been replicated in additional populations.