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rs17321515

From SNPedia

Orientationplus
Stabilizedplus
Make rs17321515(A;A)
Make rs17321515(A;G)
Make rs17321515(G;G)
ReferenceGRCh38 38.1/141
Chromosome8
Position125474167
is asnp
is mentioned by
dbSNPrs17321515
ebirs17321515
HLIrs17321515
Exacrs17321515
Varsomers17321515
Maprs17321515
PheGenIrs17321515
hapmaprs17321515
1000 genomesrs17321515
hgdprs17321515
ensemblrs17321515
gopubmedrs17321515
geneviewrs17321515
scholarrs17321515
googlers17321515
pharmgkbrs17321515
gwascentralrs17321515
openSNPrs17321515
23andMers17321515
23andMe allrs17321515
SNP Nexus

SNPshotrs17321515
SNPdbers17321515
MSV3drs17321515
GWAS Ctlgrs17321515
GMAF0.4917
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 18596051] rs17321515 influences severe hypertriglyceridemia. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched normolipidemic controls
GWAS
SNP rs17321515
PubMedID [PMID 18193043]
Condition Triglycerides
Gene TRIB1
Risk Allele A
pValue 7.00E-013
OR 6.42
95% CI NR) mg/dl highe


GWAS snp
PMID [PMID 18193044OA-icon.png]
Trait Triglycerides
Title Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Risk Allele A
P-val 4.0000000000000003E-17
Odds Ratio 0.08 [0.06-0.10] % SD lower



[PMID 19656773OA-icon.png] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia


[PMID 20692138] Polymorphism at the TRIB1 gene modulates plasma lipid levels: Insight from the spanish familial hypercholesterolemia cohort study



[PMID 22145581OA-icon.png] Association of the TRIB1 tribbles homolog 1 gene rs17321515 A>G polymorphism and serum lipid levels in the Mulao and Han populations


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 18987386] Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.


[PMID 19060910OA-icon.png] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.


[PMID 19060911OA-icon.png] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.


[PMID 19185284OA-icon.png] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.


[PMID 19197348OA-icon.png] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.


[PMID 19304782OA-icon.png] Admixture mapping of quantitative trait loci for blood lipids in African-Americans.


[PMID 19435741OA-icon.png] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.


[PMID 20972250] Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.


[PMID 21691831] Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke.


GET Evidence
rs17321515
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.421875
summary



[PMID 23596713] [SNP of rs17321515 homologous with Trib1 in Han population and its correlation with blood lipid]

GWAS snp
PMID [PMID 24386095OA-icon.png]
Trait Lipid traits
Title A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
Risk Allele A
P-val 8E-7
Odds Ratio .07 mmol/L increase


[PMID 25986010OA-icon.png] Association study of genetic variants at newly identified lipid gene TRIB1 with coronary heart disease in Chinese Han population