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rs1734787

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;C) 1.4x increased risk for lupus
(C;C) 1.4x increased risk for lupus
ReferenceGRCh38 38.1/141
ChromosomeX
Position154059995
GeneMeCP2, MECP2
is asnp
is mentioned by
dbSNPrs1734787
ebirs1734787
HLIrs1734787
Exacrs1734787
Varsomers1734787
Maprs1734787
PheGenIrs1734787
hapmaprs1734787
1000 genomesrs1734787
hgdprs1734787
ensemblrs1734787
gopubmedrs1734787
geneviewrs1734787
scholarrs1734787
googlers1734787
pharmgkbrs1734787
gwascentralrs1734787
openSNPrs1734787
23andMers1734787
23andMe allrs1734787
SNP Nexus

SNPshotrs1734787
SNPdbers1734787
MSV3drs1734787
GWAS Ctlgrs1734787
GMAF0.3398
Max Magnitude0
? (A;A) (A;C) (C;C) 28
rs1734787 is one of several SNPs in the methyl CpG binding protein 2 (MECP2) that have been associated with risk for systemic lupus erythromatosis (SLE). The MECP2 gene is located on the X chromosome, which may be instructive since lupus is a predominantly female disease.

An initial survey of 600 Korean patients, followed by 1,000 Caucasian patients, ultimately led to a meta-analysis indicating an odds ratio for the rs1734787(C) risk allele of 1.42 (CI: 1.26–1.60, p = 1.6×10e-08).[PMID 18320046OA-icon.png]


[PMID 19333917OA-icon.png] Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.